Abstract:Congenitally missing teeth (tooth agenesis) represents the most common craniofacial anomaly in man, affecting up to 20% of the population worldwide. Tooth agenesis is a clinically heterogeneous disorder affecting specific tooth types at different rates. Recent evidence also confirms the role of genetic heterogeneity in this common dental anomaly, with two genes, MSX1 and PAX9, contributing to the majority of cases published. Previous studies have associated mutations in PAX9 with molar oligodontia, while other… Show more
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