5-Year Survival Rate of Lung Cancer Patients in an Inner City Hospital

Noori, Feroz; Karippot, Asha; Kabak, Besher; Ayoub, Robby; Suffin, Daniel M.; Sandeep, Riar; Pi, Justin; Guron, Gunwant; Klukowicz, Alan; Miller, Richard A.

doi:10.1378/chest.136.4_meetingabstracts.21s-c

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“…In recent years, chemotherapy has remained the main treatment for lung cancer. Despite continuous improvements in treatment technology, the prognosis of lung cancer remains poor, and the 5-year survival rate is only approximately 15% 4,5…”

Section: Introductionmentioning

confidence: 99%

KIF5B-RET fusion gene and its correlation with clinicopathological and prognosis features in lung cancer: a meta-analysis

Cong

Yang

Chen

et al. 2019

OTT

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Background The KIF5B-RET fusion gene is a novel oncogene that has been observed in a subset of lung cancers in recent years. However, the results of related epidemiological studies remain unclear. Thus, a meta-analysis was conducted to evaluate the correlation of KIF5B-RET expression based on RT-PCR detection with clinicopathological features and prognosis of lung cancer. Methods The PubMed, Google Scholar, Wiley Online, SpringerLink and Chinese National Knowledge Infrastructure databases were searched to identify the eligible studies. The association of the occurrence of KIF5B-RET fusion gene in lung cancer with age, gender, smoking status, histology type, differentiation and TNM stage was analyzed. HR, overall survival (OS) and progression-free survival (PFS) were used to describe the prognosis of patients with lung cancer. The OR and 95% CI were calculated to assess the correlations. Random- and fixed-effects models were used to analyze the data. Results A total of 13 studies, which included 8,859 lung cancer patients, were included in the study based on the inclusion criteria. A total of 121 patients with positive KIF5B-RET fusion gene status were detected, with a positive expression rate of 1.36%. KIF5B-RET fusion gene status was identified at significantly higher frequencies in female (OR=0.67, 95% CI=0.48–0.94) than male patients, and the same trend was found in young (<60 years) patients (OR=0.08, 95% CI=0.01–0.45) compared with old patients (≥60 years). No differences were found in the TNM stage, histology, differentiation and smoking. Based on the prognosis, no difference was found between the status of the positive and negative KIF5B-RET fusion genes in OS and PFS of patients. Conclusion The KIF5B-RET fusion gene occurred predominantly in young female patients with lung cancer. However, the relationship between the expression of the fusion gene and the prognosis of lung patients remains unclear.

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Section: Introductionmentioning

confidence: 99%