5-year risk of “adult-onset” chronic diseases during childhood and adolescent transitioning for individuals with cerebral palsy

Whitney, Daniel G.

doi:10.1016/j.pmedr.2022.101933

Cited by 3 publications

(4 citation statements)

References 43 publications

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“…The patient in this case is an example of the former. The early onset of osteoarthritis and other chronic diseases in adolescent CP patients is a predictor of an increased likelihood of disease acceleration in adulthood [ 9 ]. Patients with CP are also susceptible to the same personal-level risk factors for hip osteoarthritis as those in the general population, which may exacerbate the gait-induced deformities of their hip joint.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Chronic Degenerative Hip Pain in a Male Patient With Cerebral Palsy Four Decades After Reverse Osteotomy

Hooks,

Dayya

2023

Cureus

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Patients with cerebral palsy (CP) frequently require surgical hip interventions in early adulthood due to spasticity-related gait abnormalities. In most instances, these cases are characterized by severe restrictions on mobility. This is the case of a male patient with CP who underwent right proximal femoral open reduction internal fixation (ORIF) and reverse osteotomy for right hip subluxation in young adulthood. Patients with CP who undergo total hip arthroplasty (THA) or ORIF with reverse osteotomy often require future revision. The patient was initially given an estimated 10-year longevity for his plate and screw construct (hardware). Forty-four years later, the patient presented with debilitating chronic bilateral hip pain, requiring the assistance of a cane for ambulation. There is a limited body of knowledge on ORIF and reverse osteotomy follow-up in patients with CP within a 30- to 50-year period. At the 44th-year follow-up, CT and X-ray imaging found postoperative changes in the right femur, including intact hardware, bilateral acetabular dysplasia, right femoral stress fracture, progression of hip arthritis, and right iliopsoas bursitis. Surgery for hardware revision was not indicated. Gradual restoration of function was achieved over a 14-month period with conservative management. This case suggests that physical therapy (PT), exercise, and sporadic non-steroidal anti-inflammatory drug (NSAID) use are effective for improving chronic degenerative changes, associated bursitis, and loss of function in patients who developed CP-induced gait complications in young adulthood. These improvements can be made several decades after undergoing ORIF and osteotomies. This course of treatment was effective in improving the patient’s quality of life without additional surgical interventions.

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Section: Discussionmentioning

confidence: 99%

Treatment of Chronic Degenerative Hip Pain in a Male Patient With Cerebral Palsy Four Decades After Reverse Osteotomy

Hooks,

Dayya

2023

Cureus

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“…[ 30 ] This is correlated with immune system dysfunction and cancer vulnerability. [ 34 ] The World Health Organization’s Global Action Plan for the Prevention and Control of Noncommunicable Diseases (NCDs) (including cancer) from 2013 to 2020 aimed to manage and control NCDs and their main risk factors such as obesity, smoking, inactivity, excessive alcohol consumption, and unhealthy diets in adults. [ 35 ] The lack of physical activity experienced by children with CP is a major lifetime risk factor for the development of NCDs, particularly cardiovascular problems.…”

Section: Cerebral Palsy and Mobilitymentioning

confidence: 99%

“…[ 35 ] The lack of physical activity experienced by children with CP is a major lifetime risk factor for the development of NCDs, particularly cardiovascular problems. [ 34 ] The risk of developing any malignancy (relative risk [RR] = 6.51) or metastatic disease (RR = 9.81) was higher for children with CP than for children without CP. [ 34 ] There is substantial epidemiological evidence that suggests adults who partake in more elevated levels of physical activity have a diminished probability of developing a variety of cancers compared with those who participate in lower levels of physical activity.…”

Section: Cerebral Palsy and Mobilitymentioning

confidence: 99%

“…[ 34 ] The risk of developing any malignancy (relative risk [RR] = 6.51) or metastatic disease (RR = 9.81) was higher for children with CP than for children without CP. [ 34 ] There is substantial epidemiological evidence that suggests adults who partake in more elevated levels of physical activity have a diminished probability of developing a variety of cancers compared with those who participate in lower levels of physical activity. [ 24 ] Studies show mixed results, as to whether exercise interventions result in a reduction in biomarkers linked to physical inactivity such as CRP and IL-6.…”

Section: Cerebral Palsy and Mobilitymentioning

confidence: 99%

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Mechanistic Association of Hepatoblastoma with Cerebral Palsy: A Narrative Review

Hasan,

Thomas

2024

Saudi Journal of Medicine &Amp; Medical Sciences

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Hepatoblastoma is a rare liver cancer that occurs most often in children who present with lower birth weight. Cerebral palsy (CP) is a neurodevelopmental disorder distinguished by irregularities in muscle tone, movement, and motor skills. CP is caused by damage to the developing brain and is often associated with secondary complications such as severe constipation. Clinicians must be aware of sudden worsening constipation occurring in CP children because it can also be a sign of hepatoblastoma. The aim of this review is to summarize the current understanding of the risks for hepatoblastoma development in children with CP. Cancer risks likely include dysfunction of the immune system surveillance in CP children. Elevated C-reactive protein and tumor necrosis factor-alpha levels may be higher in children with CP, which weakens their innate immune system. Metabolic disruption increases the risk of some cancers, and poor nutrition and reduced growth that occur in CP patients may have an impact on cancer development through a loss in immune function. Increased mobility and physical activity can increase the T-cell, natural killer cell, and neutrophil population. Children with CP tend to engage poorly in physical activity, and consequently, their immune system is affected. There are multiple factors associated with CP that increase the risk of childhood cancers such as hepatoblastoma.

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Home-based motorised cycling in Non-ambulant adults with cerebral palsy: a feasibility study

Holmes,

Shields,

Morgan

et al. 2024

Disability and Rehabilitation

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5-year risk of “adult-onset” chronic diseases during childhood and adolescent transitioning for individuals with cerebral palsy

Cited by 3 publications

References 43 publications

Treatment of Chronic Degenerative Hip Pain in a Male Patient With Cerebral Palsy Four Decades After Reverse Osteotomy

Treatment of Chronic Degenerative Hip Pain in a Male Patient With Cerebral Palsy Four Decades After Reverse Osteotomy

Mechanistic Association of Hepatoblastoma with Cerebral Palsy: A Narrative Review

Home-based motorised cycling in Non-ambulant adults with cerebral palsy: a feasibility study

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