5-Year Results from the ISHLT DCD Lung Transplant Registry Confirm Excellent Recipient Survival from Donation after Circulatory Death Donors

Raemdonck, Dirk Van; Keshavjee, Shaf; Levvey, Bronwyn; Cherikh, Wida S.; Snell, Greg; Erasmus, Michiel E.; Simón, A.; Glanville, Allan R.; Clark, Stephen; D’Ovidio, Frank; Catarino, Pedro; McCurry, Kenneth R.; Hertz, Marshall I.; Venkateswaran, R.; Hopkins, Peter; İnci, İlhan; Walia, Rajat; Kreisel, Daniel; Mascaro, Jorge; Dilling, Daniel F.; Camp, Phillip C.; Mason, David P.; Musk, M.; Burch, Michael; Fisher, Andrew J.; Yusen, Roger D.; Stehlik, Josef; Cypel, Marcelo

doi:10.1016/j.healun.2019.01.241

Cited by 12 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In regard to survival, the large International Society for Heart and Lung Transplant (ISHLT) DCD Registry reports comparable 5-year survival rate of 1026 cDCD-lung transplants in comparison with 10 426 DBD-lung transplants. 34 Moreover, the 10-year survival of cDCD-lung transplants was superior as revealed in the most recent ISHLT Annual Report. 35 The most recent United Network for Organ Sharing (UNOS) Registry data analysis showed similar results for 10year survival for 389 cDCD compared with 20 516 DBD-lung transplants.…”

Section: Survivalmentioning

confidence: 98%

Current status and further potential of lung donation after circulatory death

Ehrsam

Benden

Immer³

et al. 2021

Clinical Transplantation

View full text Add to dashboard Cite

Lung transplantation is the only successful treatment option for endstage lung diseases. Over the last decades, lung transplantation has steadily improved, and in parallel, indications were broadened and contraindication eased. While the demand is still increasing worldwide, a chronic organ shortage remains the primary limiting factor in lung transplantation. A concerning wait-list mortality is currently reported by the Organ Procurement and Transplantation Network (OPTN), increasing within a decade from 15% to 20%. 1 Since more than 50 years, donation after brain death (DBD) has been the leading source of deceased donation worldwide. In DBD donors, the lung is the most fragile and vulnerable of all solid organs, and only 15%-30% of these lungs are generally utilized for transplantation. 1 One reason is a neurogenic pulmonary edema caused by upregulation of inflammatory mediators attributed to brain death. Besides this, lungs are vulnerable due to frequent aspiration of gastric contents, pulmonary infections, contusion, and ventilation-associated lung injury. To overcome the critical organ shortage, many centers have started to use marginal donor lungs, size reduced allografts, and, in few cases, living lobar donation. However, the latter attempts have just led to a small increase in the donor pool so far. In contrast, the

show abstract

Section: Survivalmentioning

confidence: 98%

Current status and further potential of lung donation after circulatory death

Ehrsam

Benden

Immer³

et al. 2021

Clinical Transplantation

View full text Add to dashboard Cite

show abstract

“…There are various strategies to increase the donor pool; these include legislative action, public campaigns, in-hospital training programs, extending the selection criteria for lung donors, and using from lungs from donors who died after circulatory arrest (DCD) [2]. A study from the ISHLT DCD registry showed that outcomes of DCD were similar to DBD [19]. This is confirmed in our cohort: [HR: 0.79 (95% CI: 0.59-1.05), P = 0.10].…”

Section: Discussionmentioning

confidence: 99%

Impact of donor lung quality on post‐transplant recipient outcome in the Lung Allocation Score era in Eurotransplant – a historical prospective study

et al. 2020

View full text Add to dashboard Cite

The aim of this study was to investigate whether there is an impact of donation rates on the quality of lungs used for transplantation and whether donor lung quality affects post-transplant outcome in the current Lung Allocation Score era. All consecutive adult LTx performed in Eurotransplant (ET) between January 2012 and December 2016 were included (N = 3053). Donors used for LTx in countries with high donation rate were younger (42% vs. 33% ≤45 years, P < 0.0001), were less often smokers (35% vs. 46%, P < 0.0001), had more often clear chest X-rays (82% vs. 72%, P < 0.0001), had better donor oxygenation ratios (20% vs. 26% with PaO 2 /FiO 2 ≤ 300 mmHg, P < 0.0001), and had better lung donor score values (LDS; 28% vs. 17% with LDS = 6, P < 0.0001) compared with donors used for LTx in countries with low donation rate. Survival rates for the groups LDS = 6 and ≥7 at 5 years were 69.7% and 60.9% (P = 0.007). Lung donor quality significantly impacts on long-term patient survival. Countries with a low donation rate are more oriented to using donor lungs with a lesser quality compared to countries with a high donation rate. Instead of further stretching donor eligibility criteria, the full potential of the donor pool should be realized.

show abstract

“…Among the participating centers, the proportion of DCD lung transplant increased from 0.6% in 2003 to 15.2% in 2017. One-and 5-year actuarial survival was 97% and 90% in DCD, vs. 90% and 61%, for 503 DBD lung transplants, respectively (9).…”

Section: Lung Transplantation and Donation After Cardiac Deathmentioning

confidence: 92%

Ethical subjects in lung transplant and current era

Makdisi¹

2023

Curr Chall Thorac Surg

View full text Add to dashboard Cite

General principals of biomedical ethicsLung transplantation has become a viable treatment option for many patients with terminal pulmonary disease, but the lack of available donors adds more constrains to already difficult and lengthy process. Sadly, many patients listed for lung transplant die while awaiting transplantation (1).Due to the fact that organs recovered from deceased donors offer substantial (and sometimes superior) benefits to potential recipients, with no risk to a healthy live donor, the efforts to maximize the use of organs from deceased donors must not be impeded by the development of live organ donation (2).Understanding the fundamental principles of biomedical ethics will help analyzing the complex medical situation that physicians often encounter such as organ transplantation.There are four principles: Beneficence which means "do good", non-maleficence "do no harm", autonomy which means making sure that the patients fully understand their options and that their decisions are respected, and Justice which means trying to advocate and invest the medical resources equally to all patients regardless of any factor including social economic status (3). Applying general biomedical ethical concepts in lung transplantIn lung transplant, Beneficence means that this ethical principal is clearly being met in all transplant patients as a group. In other words, the quality of life of some patients is

show abstract

5-Year Results from the ISHLT DCD Lung Transplant Registry Confirm Excellent Recipient Survival from Donation after Circulatory Death Donors

Cited by 12 publications

References 0 publications

Current status and further potential of lung donation after circulatory death

Current status and further potential of lung donation after circulatory death

Impact of donor lung quality on post‐transplant recipient outcome in the Lung Allocation Score era in Eurotransplant – a historical prospective study

Ethical subjects in lung transplant and current era

Contact Info

Product

Resources

About