5-year outcome of an interventional strategy in non-ST-elevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial

Fox, Keith A.A.; Poole‐Wilson, Philip A.; Clayton, Tim; Henderson, Robert A.; Shaw, T. R. D.; Wheatley, David J.; Knight, Rosemary; Pocock, Stuart J.

doi:10.1016/s0140-6736(05)67222-4

Cited by 321 publications

(206 citation statements)

References 14 publications

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“…This is a high value when compared to data from higher-risk randomized controlled trials, but it was a similar value to that observed in the RITA 3 (Randomized Intervention Trial on unstable Angina) trial, where in a lower risk population, 28% of patients allocated for an invasive strategy had a normal coronary angiogram 14 .…”

Section: Baseline Datasupporting

confidence: 76%

A importância de um EGC normal em síndromes coronarianas agudas sem supradesnivelamento do segmento ST

Teixeira¹,

Lourenço²,

António³

et al. 2010

Arq. Bras. Cardiol.

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Section: Baseline Datasupporting

confidence: 76%

A importância de um EGC normal em síndromes coronarianas agudas sem supradesnivelamento do segmento ST

Teixeira¹,

Lourenço²,

António³

et al. 2010

Arq. Bras. Cardiol.

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“…With these developments, recurrent ischemic complications have been substantially reduced (21,22) and long-term survival has improved (23). However, the improved outcomes came with an increased risk of major hemorrhage.…”

Section: Management Strategy and Bleedingmentioning

confidence: 99%

The impact of bleeding in patients with acute coronary syndromes: How to optimize the benefits of treatment and minimize the risk

Fitchett

2007

Canadian Journal of Cardiology

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“…Several meta-analyses that included contemporary randomized, controlled trials (RCTs) have shown a substantial risk reduction in all-cause mortality and myocardial infarction (MI) at 1 to 2 years after an early invasive strategy, 1,2 particularly in patients with the highest risk profile. 3 The treatment of choice, whether percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), is based on the same considerations used for patients with stable coronary artery disease. 4 Approximately 7% to 13% of patients hospitalized with NSTEMI undergo in-hospital CABG, 5,6 about a third performed within 48 hours of hospital admission.…”

mentioning

confidence: 99%

Does Timing of Coronary Artery Bypass Surgery Affect Early and Long-Term Outcomes in Patients With Non–ST-Segment–Elevation Myocardial Infarction?

et al. 2015

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Background-Current guidelines do not provide recommendations for optimal timing of coronary artery bypass surgery (CABG) in patients with non-ST-segment-elevation myocardial infarction. Our study aimed to determine the impact of CABG timing on early and late outcomes in patients with non-ST-segment-elevation myocardial infarction. Methods and Results-A total of 758 patients underwent CABG within 21 days after non-ST-segment-elevation myocardial infarction between January 2008 and December 2012 at our institution. The patients were divided into 3 groups according to the time interval between symptom onset and CABG: group A, <24 hours (133 patients); group B, 24 to 72 hours (192 patients); and group C, >72 hours to 21 days (433 patients). Predictors of in-hospital and long-term mortality were identified by logistic and Cox regression analyses, respectively. Overall in-hospital mortality was 5.1% (39 patients): 6.0%, 4.7%, and 5.1% in groups A, B, and C (P=0.9), respectively. A total of 118 patients died during follow-up. The 5-year survival was 73.1±2%, with a nonsignificant trend toward better survival in groups A (78.2±4%) and C (75.4±3%) compared with group B (63.6±5%; log-rank P=0.06). Renal insufficiency and LMD were independent predictors of in-hospital (odds ratio, 3.1; P=0.001; and odds ratio, 3.1; P=0.002) and long-term mortality (hazard ratio, 1.7; P=0.004; and hazard ratio, 1.5; P=0.02), whereas administration of P2Y 12 inhibitors was protective (odds ratio, 0.3; P=0.01). Conclusions-Emergent CABG within 24 hours of non-ST-segment-elevation myocardial infarction is associated with in-hospital mortality and long-term outcomes similar to those of CABG performed after 3 days, despite a higher risk profile. CABG performed between 24 to 72 hours showed a nonsignificant trend toward poorer long-term outcomes. Dual antiplatelet therapy until surgery is beneficial, whereas renal insufficiency and left main disease increase the risk of early and late death. (Circulation. 2015;132:731-740.

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5-year outcome of an interventional strategy in non-ST-elevation acute coronary syndrome: the British Heart Foundation RITA 3 randomised trial

Cited by 321 publications

References 14 publications

A importância de um EGC normal em síndromes coronarianas agudas sem supradesnivelamento do segmento ST

A importância de um EGC normal em síndromes coronarianas agudas sem supradesnivelamento do segmento ST

The impact of bleeding in patients with acute coronary syndromes: How to optimize the benefits of treatment and minimize the risk

Does Timing of Coronary Artery Bypass Surgery Affect Early and Long-Term Outcomes in Patients With Non–ST-Segment–Elevation Myocardial Infarction?

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