5 The Control of Central Neural Hyperexcitability in Magnesium Deficiency

Electromyographical ischemic test, clinical symptoms related to neuromuscular hyperexcitability, and intra- and extracellular Mg++ levels in headache patients

“…The percentages of migraine patients with positive ischemic tests and mononuclear cells and serum Mg ++ levels below the cut-off point defining the normalcy were lower (81.1% and 72.2%, respectively). This finding further supports the superiority of the determination of Mg ++ levels in erythrocytes not only as a sensitive indicator of magnesium nutritional status, but also as an indirect marker of muscular excitability, compared to the magnesium concentration in other body compartments such as mononuclear cells and particularly serum [18,21,22,26,27].…”

“…On the other hand, there is recurring evidence, since the early 1960s, that a relative or absolute lack of Mg ++ is related to certain neurological conditions such as criptotetany, latent tetany, hyperventilation syndrome and spasmophilia [10][11][12][13][14][15][16][17]. The latter has recently been referred to as the central neuronal hyperexcitability syndrome (NHS) [18,19]. Headache has often been described to be associated with the neuronal hyperexcitability syndrome (NHS), but no clear clinical characterization of this association is available [14][15][16].…”

Spasmophilia in the Cardiological Outpatient Department: A Retrospective Study of 228 Sub-saharan Africans over 5 Years

“…This difference is probably due to the superiority of the determination of Mg ++ levels in erythrocytes not only as a sensitive indicator of magnesium nutritional status, but also as an indirect marker of muscular excitability, compared to the magnesium concentration in other body compartments such as mononuclear cells and particularly serum [1,20,21].…”

Magnesium in the Central Nervous System

“…Because of the important interaction between phosphate and magnesium ions, magnesium ions are essential to the basic nucleic acid chemistry of life, and thus are essential to all cells of all known living organisms. Magnesium is involved in the formation of phospholipids and the insertion of proteins into the phospholipid membrane, and is therefore critical to membrane stabilization (Durlach et al, 1987). It also contributes to contraction of the cytoskeleton at the myoneural junction, playing a vital role in the function of both skeletal, cardiac and other smooth muscles.…”

“…We should emphasize that the nervous consequences of magnesium deficiency remain functional with an atomical integrity for a long time. They are, however, completely reversible since they can be restored to normal with simple oral physiological magnesium supplementation (Durlach et al, 1987;. Neuroticism Neuroticism is a fundamental personality trait in the study of psychology.…”