5 Risk screening tools for engineered nanomaterials

U. S. federal perspective on critical research issues in nanoEHS

“…34 This work would support the development of more sophisticated tools and new approach methods, including adverse outcome pathway (AOP) models that could support the design of tiered testing strategies to evaluate the safety of nanomaterials or advanced materials. [35][36][37] The AOP concept links molecular perturbations (e.g., molecular initiation events) and cellular responses (e.g., key events) with adverse outcomes to organisms and populations. Highthroughput toxicity testing (HTT) and screening (HTS) 38 can be used to evaluate these key events for a broad range of particles.…”

“…34 This work would support the development of more sophisticated tools and new approach methods, including adverse outcome pathway (AOP) models that could support the design of tiered testing strategies to evaluate the safety of nanomaterials or advanced materials. 35–37 The AOP concept links molecular perturbations ( e.g. , molecular initiation events) and cellular responses ( e.g.…”