5′‐O‐Fluorosulfonylbenzoyl Esters of Purine Nucleosides as Potential Inhibitors of NTPase/Helicase and Polymerase of Flaviviridae Viruses

Bretner, Maria; Schalinski, Sarah; Borowski, Peter; Kulikowski, Tadeusz

doi:10.1002/chin.200408230

Cited by 1 publication

(2 citation statements)

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“…Such a mechanism could modulate the efficacy of the unwinding reaction or NTPase activity of the enzyme and therefore, affect the viral replication process. 117–121 Weak inhibitory effects on flaviviral NTPase/helicases were described for ribavirin triphosphate, 124,125 5′- O -fluorosulfonylbenzoyl esters of purine nucleosides, 126,127 or halogenated benzotriazole-modified nucleosides. 30,122 These compounds were primarily evaluated in enzyme-based assays for their putative anti-HCV activity; however, some of them have been found to inhibit also NTPase/helicases of WNV, JEV, or DENV.…”

Section: Nucleoside Inhibitors Of Flaviviral Ntpase/helicasementioning

confidence: 99%

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Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses

Eyer

Nencka

Clercq

et al. 2018

Antivir Chem Chemother

118

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Nucleoside analogs represent the largest class of small molecule-based antivirals, which currently form the backbone of chemotherapy of chronic infections caused by HIV, hepatitis B or C viruses, and herpes viruses. High antiviral potency and favorable pharmacokinetics parameters make some nucleoside analogs suitable also for the treatment of acute infections caused by other medically important RNA and DNA viruses. This review summarizes available information on antiviral research of nucleoside analogs against arthropod-borne members of the genus Flavivirus within the family Flaviviridae, being primarily focused on description of nucleoside inhibitors of flaviviral RNA-dependent RNA polymerase, methyltransferase, and helicase/NTPase. Inhibitors of intracellular nucleoside synthesis and newly discovered nucleoside derivatives with high antiflavivirus potency, whose modes of action are currently not completely understood, have drawn attention. Moreover, this review highlights important challenges and complications in nucleoside analog development and suggests possible strategies to overcome these limitations.

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Section: Nucleoside Inhibitors Of Flaviviral Ntpase/helicasementioning

confidence: 99%

“…30,122 These compounds were primarily evaluated in enzyme-based assays for their putative anti-HCV activity; however, some of them have been found to inhibit also NTPase/helicases of WNV, JEV, or DENV. 117–127…”

Section: Nucleoside Inhibitors Of Flaviviral Ntpase/helicasementioning

confidence: 99%