5-Methylcoumaranones from Mutisia friesiana and Their Bioactivity

Viturro, Carmen I.; Fuente, Juana R. de la; Maier, Marta S.

doi:10.1021/np0304058

Cited by 10 publications

(3 citation statements)

References 15 publications

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“…Benzofuranones are an important class of heterocycles existing in a number of natural products and bioactive molecules . Among them, 2,2‐disubstituted benzofuran‐3(2 H )‐ones are frequently found in a variety of pharmaceutically‐active compounds, such as mutisicoumaranone A (antifungal activity), griseofulvin (antifungal agent),– spiroapplanatumines (kinase inhibitors), geodin (antibacterial activity and glucose uptake stimulatory activity),– linobiflavonoid (antitumor), Sch 202596 (non‐peptidic antagonist of the galanin receptor subtype GalR1), armeniaspirols A−C (antibiotic activity), as well as many others . Consequently, the development of efficient methods for the synthesis of 2,2‐disubstituted benzofuran‐3(2 H )‐ones are of remarkable value.…”

Section: Methodsmentioning

confidence: 99%

Direct Oxidative Disulfenylation/Cyclization of 2′‐Hydroxyacetophenones with Thiophenols for the Synthesis of 2,2‐Dithio‐Benzofuran‐3(2H)‐Ones

Zhang

Zhao

et al. 2018

Adv Synth Catal

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A direct oxidative disulfenylation/cyclization of 2'-hydroxyacetophenones with thiophenols mediated by TBAI/K 2 S 2 O 8 has been successfully developed within this study. The reaction successfully provides an efficient method for the synthesis of functionalized 2,2-dithio-benzofuran-3(2H)-ones, which exhibits readily available starting materials, a broad substrate scope, excellent yields, and large-scale applicability. In a single step, two CÀS bonds and one CÀO bond are simultaneously built on the same sp 3 carbon atom under transitionmetal-free conditions.

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Section: Methodsmentioning

confidence: 99%

Direct Oxidative Disulfenylation/Cyclization of 2′‐Hydroxyacetophenones with Thiophenols for the Synthesis of 2,2‐Dithio‐Benzofuran‐3(2H)‐Ones

Zhang

Zhao

et al. 2018

Adv Synth Catal

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“…Growth inhibition by essential oil (α-pinene,β-pinene, limonene, β-myrcene) and n-hexane extract containing polygodial (6), drimenol (7), drimenin (8) De Menezes et al, 2014), and the closely related multisicoumaranones A (17), B, C and D, resulted toxic to Cladosporium species (Viturro et al, 2004). Phenolic and polyphenolic compounds (Figure 1) of twelve vegetable species have shown broad-spectrum fungicide activity against eleven fungus genera, the active compounds isolated are ellagitannin (18), trifolin (19), hyperoside (20), lignans (21,22), chalcones (23, 24), a caffeic acid derivative (25) and flavanone (26).…”

Section: Gaeumannomyces Graminismentioning

confidence: 99%

Plant-Derived Natural Products From the American Continent for the Control of Phytopathogenic Fungi: A Review

Ramirez-Mares¹,

Hernández-Carlos²

2015

JGIASS

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Various pathogenic microorganisms affect plants. However, most diseases are caused by fungi, which have an enormous reproductive capacity and possess metabolic mechanisms capable to develop resistance to commercial fungicides. Fungi produce mycotoxins on crops and this represents a considerable risk to human and animal health. The most important genera of phytopathogenic fungi of the American continent are: Aspergillus, Alternaria, Botrytis, Colletotrichum, Fusarium, Phytophthora, Penicillium and Pythium, among others. Different strategies have been used for phytopatogenic fungi control, mainly by using synthetic fungicides. Currently, a great deal of attention has been paid towards exploitation of higher plant products as an innovative alternative in crops protection. The use of plant derived natural products has many advantages, such as little or no harmful side effects, rare cases of resistance, long-term control and completely or substantially eliminates the use of synthetic fungicides. Several plants belonging to the Anacardiaceae, Asteraceae, Caprifoliaceae, Lamiaceae, Liliaceae, Papilionacea, Poaceae, Verbenaceae, families, have showed fungicide potential. Therefore, this review addresses occurrence of the most important phytopatogenic fungi and the current state of research regarding the potential of vegetable biodiversity in the development of plant derived natural products for the management of these pathogens in the American continent.

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“…138 Guided-fractionation using Fusarium verticillioides as test organisms led to the isolation of scopoletin, which had a IC 50 value of 1.5 mg/ml in the microbroth dilution method. The methanol extract of the aerial parts of the shrub Mutisia friesiana Cabrera (Asteraceae) afforded two new 5-methylcoumarins, mutisicoumarones C and D. 139 The compounds showed antifungal effect against the phytopathogenic fungus Cladosporium cucumerinum.…”

mentioning

confidence: 99%

Active antifungal substances from natural sources

Abad¹,

Ansuategui²,

Bermejo³

2006

Arkivoc

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The spread of multidrug-resistant strains of fungus and the reduced number of drugs available, makes it necessary to discover new classes of antifungals and compounds that inhibit these resistant mechanisms. This has led to a search for therapeutic alternatives, particularly among medicinal plants and compounds isolated from them used for their empirically antifungal properties. In these natural sources, a series of molecules with antifungal activity against different strains of fungus have been found, which are of great importance to humans and plants. In this article, we review the main sources of molecules with antimycotic activity obtained from the natural environment.

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5-Methylcoumaranones from Mutisia friesiana and Their Bioactivity

Cited by 10 publications

References 15 publications

Direct Oxidative Disulfenylation/Cyclization of 2′‐Hydroxyacetophenones with Thiophenols for the Synthesis of 2,2‐Dithio‐Benzofuran‐3(2H)‐Ones

Direct Oxidative Disulfenylation/Cyclization of 2′‐Hydroxyacetophenones with Thiophenols for the Synthesis of 2,2‐Dithio‐Benzofuran‐3(2H)‐Ones

Plant-Derived Natural Products From the American Continent for the Control of Phytopathogenic Fungi: A Review

Active antifungal substances from natural sources

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