5-Methoxyisatin N(4)-Pyrrolidinyl Thiosemicarbazone (MeOIstPyrd) Restores Mutant p53 and Inhibits the Growth of Skin Cancer Cells, In Vitro
Nerina Shahi,
Paras Nath Yadav,
Upendra Chaudhary
et al.
Abstract:A series of novel thiosemicarbazone derivatives containing 5-methoxy isatin were designed and synthesized with modification on N(4) position. Derivatives considering structure−activity relationship have been designed and synthesized by condensing thiosemicarbazide with 5-methoxy isatin. The synthesized compounds were characterized by elemental analysis, FT-IR spectroscopy, UV−visible spectroscopy, NMR ( 1 H, 13 C) spectroscopy, mass spectrometry, and a single-crystal study. Biological evaluation of the synthes… Show more
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