5-Methoxyindole-2-Carboylic Acid (MICA) Fails to Retard Development and Progression of Type II Diabetes in ZSF1 Diabetic Rats

Li, Chunyan; Ma, Weixing; Yan, Liang-Jun

doi:10.20455/ros.2020.821

Cited by 1 publication

(2 citation statements)

References 22 publications

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“…As mentioned above, this NA-STZ diabetes animal model is a non-obese type 2 diabetes model [ 23 ]. The pathogenesis of diabetes in this model may be different from that of HFD/STZ or genetically engineered models, such as the db/db mouse model and the zsf1 obese rat model [ 30 , 94 , 95 , 96 ]. Nevertheless, the NA-STZ model may provide a unique platform for the study of non-obese diabetes and diabetic complications [ 43 , 97 ].…”

Section: Application Of This Model In Dn Researchmentioning

confidence: 99%

“…This non-obese type 2 diabetes animal model was initially established in rats [ 24 ] but has since been extended to include mice with modifications of the original protocol. In comparison with the high-fat-diet (HFD)-STZ-induced type 2 diabetes animal models [ 25 , 26 , 27 , 28 ] and genetically engineered diabetic animal models, such as db/db mice [ 29 ] and zsf1 obese rats [ 30 ], the NA/STZ model is time-saving and less expensive. Therefore, this model can be equally used as a platform for not only exploring the pathogenesis of DN but also screening and testing potential antidiabetic agents [ 31 ] or renoprotective compounds for their therapeutic effects [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features

2022

Biomolecules

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Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has been a great advance in our understanding of the pathogenesis of DN, no effective managements of this chronic kidney disease are currently available. Therefore, continuing to elucidate the underlying biochemical and molecular mechanisms of DN remains a constant need. In this regard, animal models of diabetes are indispensable tools. This review article highlights a widely used rodent model of non-obese type 2 diabetes induced by nicotinamide (NA) and streptozotocin (STZ). The mechanism underlying diabetes induction by combining the two chemicals involves blunting the toxic effect of STZ by NA so that only a percentage of β cells are destroyed and the remaining viable β cells can still respond to glucose stimulation. This NA-STZ animal model, as a platform for the testing of numerous antidiabetic and renoprotective materials, is also discussed. In comparison with other type 2 diabetic animal models, such as high-fat-diet/STZ models and genetically engineered rodent models, the NA-STZ model is non-obese and is less time-consuming and less expensive to create. Given that this unique model mimics certain pathological features of human DN, this model should continue to find its applications in the field of diabetes research.

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Section: Application Of This Model In Dn Researchmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

5-Methoxyindole-2-Carboylic Acid (MICA) Fails to Retard Development and Progression of Type II Diabetes in ZSF1 Diabetic Rats

Cited by 1 publication

References 22 publications

The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features

The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features

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