5% Lidocaine Medicated Plaster Use in Children with Neuropathic Pain from Burn Sequelae

Silva, Matias Orellana; Yañez, Veronica; Hidalgo, Gabriela; Valenzuela, Fernando; Saavedra, Rolando

doi:10.1111/pme.12020

Cited by 21 publications

(14 citation statements)

References 28 publications

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“…Nayak and colleagues reported their utilization in 5 adolescents with chronic localized neuropathic pain; symptoms were thoroughly evicted in 4 patients with good clinical tolerance . A prospective study conducted in 14 pediatric patients suffering from burn sequelae showed a significant efficacy in 11 of the 12 patients available for clinical assessment through a decrease in the mean pain intensity on the FACES scale from 6.8 to 0, and a decrease in the mean neuropathic pain score in 4 questions (DN4) from 6 to 2.3, without any adverse reactions …”

Section: Introductionmentioning

confidence: 99%

Efficacy and Tolerance of Lidocaine 5% Patches in Neuropathic Pain and Pain Related to Vaso‐occlusive Sickle Cell Crises in Children: A Prospective Multicenter Clinical Study

Rousseau

Morelle

Arriuberge³

et al. 2018

Pain Practice

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Section: Introductionmentioning

confidence: 99%

Efficacy and Tolerance of Lidocaine 5% Patches in Neuropathic Pain and Pain Related to Vaso‐occlusive Sickle Cell Crises in Children: A Prospective Multicenter Clinical Study

Rousseau

Morelle

Arriuberge³

et al. 2018

Pain Practice

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“…A limited number of studies indicate that 60-100% of children suffering from a peripheral neuropathy benefit from lidocaine patches. [11][12][13]16 Varying success rates are related to differences in neuropathic pain conditions, treatment duration, and definition of outcome. A large study in 115 children reported that 69% benefitted from the use of lidocaine patches (on multiple outcomes).…”

Section: Discussionmentioning

confidence: 99%

“…Incidental adverse events are mild to moderate local skin reactions such as erythema, rash, or pruritus. [12][13][14]16 Several studies showed that lidocaine plasma concentrations during patch treatment remained well below systemic therapeutic and toxic ranges in both adults and children. 13,17,18 Thus, lidocaine patches may be a potential safe and noninvasive treatment option in childhood ACNES.…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14]16 Several studies showed that lidocaine plasma concentrations during patch treatment remained well below systemic therapeutic and toxic ranges in both adults and children. 13,17,18 Thus, lidocaine patches may be a potential safe and noninvasive treatment option in childhood ACNES. The present retrospective case series is the first to assess the effects of lidocaine patches in a pediatric population with ACNES.…”

Section: Introductionmentioning

confidence: 99%

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Lidocaine patch as noninvasive alternative treatment option in children with anterior cutaneous nerve entrapment syndrome: A retrospective case series

ten Have,

Zwaans,

Scheltinga

et al. 2024

Pediatric Anesthesia

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BackgroundChronic abdominal pain in children is occasionally caused by anterior cutaneous nerve entrapment syndrome (ACNES). Diagnosing and treating this typical peripheral abdominal wall neuropathy is challenging. Management usually starts with minimally invasive tender point injections. Nevertheless, these injections can be burdensome and might even be refused by children or their parents. However, a surgical neurectomy is far more invasive. Treatment with a Lidocaine 5% medicated patch is successfully used in a variety of peripheral neuropathies.AimsThis single center retrospective case series aimed to evaluate the effectiveness and tolerability of lidocaine patches in children with ACNES.MethodsChildren aged under 18 diagnosed with ACNES who were treated with a 10 day lidocaine patch treatment between December 2021 and December 2022 were studied. Patient record files were used to collect treatment outcomes including pain reduction based on NRS and complications.ResultsTwelve of sixteen children (mean age 13 years; F:M ratio 3:1) diagnosed with ACNES started the lidocaine patch treatment. Two patients achieved a pain free status and remained pain free during a 4 and 7 months follow‐up. A third child reported a lasting pain reduction, but discontinued treatment due to a temporary local skin rash. Five additional patients reported pain reduction only during application of the patch. The remaining four children experienced no pain relief. No adverse effects were reported.ConclusionLidocaine patches provides pain relief in a substantial portion of children with ACNES.

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“…In addition to its efficacy and safety in PHN and DPN, the 5% lidocaine medicated plaster has been evaluated in a diverse range of other LNP conditions, including myofascial pain syndrome, 52 – 54 burn sequelae in children, 55 cervical radiculopathy, 56 inguinal postherniorrhaphy pain, 57 postsurgical neuropathic pain in patients with cancer, 58 cancer pain with neuropathic components or trigeminal neuropathic pain, 59 orofacial pain, 60 persistent postmastectomy pain, 61 and various other conditions 62 ( Table 2 ). Most reports indicate clinical benefits with the 5% lidocaine medicated plaster in various LNP conditions.…”

Section: Clinical Evidence With the Topical 5% Lidocaine Medicated Plmentioning

confidence: 99%

The topical 5% lidocaine medicated plaster in localized neuropathic pain: a reappraisal of the clinical evidence

León-Casasola¹,

Mayoral²

2016

JPR

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Topical 5% lidocaine medicated plasters represent a well-established first-line option for the treatment of peripheral localized neuropathic pain (LNP). This review provides an updated overview of the clinical evidence (randomized, controlled, and open-label clinical studies, real-life daily clinical practice, and case series). The 5% lidocaine medicated plaster effectively provides pain relief in postherpetic neuralgia, and data from a large open-label controlled study indicate that the 5% lidocaine medicated plaster is as effective as systemic pregabalin in postherpetic neuralgia and painful diabetic polyneuropathy but with an improved tolerability profile. Additionally, improved analgesia and fewer side effects were experienced by patients treated synchronously with the 5% lidocaine medicated plaster, further demonstrating the value of multimodal analgesia in LNP. The 5% lidocaine medicated plaster provides continued benefit after long-term (≤7 years) use and is also effective in various other LNP conditions. Minor application-site reactions are the most common adverse events associated with the 5% lidocaine medicated plaster; there is minimal risk of systemic adverse events and drug–drug interactions. Although further well-controlled studies are warranted, the 5% lidocaine medicated plaster is efficacious and safe in LNP and may have particular clinical benefit in elderly and/or medically compromised patients because of the low incidence of adverse events.

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5% Lidocaine Medicated Plaster Use in Children with Neuropathic Pain from Burn Sequelae

Abstract: These are the first published data suggesting that 5% lidocaine medicated plaster improves patient functionality, and is effective and safe for the treatment of neuropathic pain in pediatric patients with burn sequelae.

Cited by 21 publications

References 28 publications

Efficacy and Tolerance of Lidocaine 5% Patches in Neuropathic Pain and Pain Related to Vaso‐occlusive Sickle Cell Crises in Children: A Prospective Multicenter Clinical Study

Efficacy and Tolerance of Lidocaine 5% Patches in Neuropathic Pain and Pain Related to Vaso‐occlusive Sickle Cell Crises in Children: A Prospective Multicenter Clinical Study

Lidocaine patch as noninvasive alternative treatment option in children with anterior cutaneous nerve entrapment syndrome: A retrospective case series

The topical 5% lidocaine medicated plaster in localized neuropathic pain: a reappraisal of the clinical evidence

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