Abstract:The effects of serotonin (5‐hydroxytryptamine, or 5‐HT) on the neurophysiologic behavior of guinea pig gastric myenteric neurons were investigated in vitro using conventional intracellular recording methods. The predominant effect consisted of a brief, rapidly desensitizing depolarization in 48 of 78 neurons. During the depolarization the membrane resistance decreased and the excitability of the neurons increased, as indicated by action potential discharge during previously subthreshold depolarizing current pu… Show more
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