5-Hydroxytryptamine (5-HT) receptors mediate the release and action of secretin on pancreatic secretion induced by duodenal acidification in rats

Li, P; Chang, Tsun-Hou; Wy, Chey

doi:10.1016/s0016-5085(98)84710-0

Gastroenterology

1998

DOI: 10.1016/s0016-5085(98)84710-0

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5-Hydroxytryptamine (5-HT) receptors mediate the release and action of secretin on pancreatic secretion induced by duodenal acidification in rats

P Li¹,

Tsun-Hou Chang²,

Chey Wy³

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2001

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“…27), gastrin-releasing peptide (GRP; see Ref. 30), or serotonin (29), also stimulate or are involved in the release of secretin. It has been reported that secretin-releasing peptides exist in both the upper small intestine (31) and pancreatic juice (32) to mediate the release of endogenous secretin in the dog (42) and rat (32).…”

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Pancreatic phospholipase A₂from the small intestine is a secretin-releasing factor in rats

Chang

Wagner

et al. 2001

American Journal of Physiology-Gastrointestinal and Liver Physi

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A secretin-releasing activity exists in the upper small intestine and pancreatic juice in the rat and the dog. Group I pancreatic phospholipase A2 (PLA2) in canine pancreatic juice and porcine pancreatic PLA2 stimulate the release of secretin from both STC-1 cells and a secretin-producing cell (S cell)-enriched preparation isolated from rat duodenal mucosa. We investigated the distribution and release of pancreatic PLA2-like immunoreactivity in the gastrointestinal tract and the role of PLA2 on the release of secretin and pancreatic exocrine secretion in response to duodenal acidification in anesthetized rats. PLA2-like immunoreactivity was detected in the mucosa throughout the gastrointestinal tract. High concentrations of PLA2 were found in both the small intestine and the pancreas. Duodenal acidification significantly increased the release of PLA2 from the upper small intestine (385% over basal secretion). Intravenous infusion of an anti-PLA2 serum (anti-PLA2) dose-dependently inhibited the release of secretin and pancreatic exocrine secretion in response to duodenal acid perfusion. Preincubation of the concentrate of intestinal acid perfusate (10-fold) from donor rats with the anti-PLA2 significantly suppressed its stimulation of secretin release and pancreatic exocrine secretion in recipient rats. We conclude that pancreatic PLA2 also functions as a secretin-releasing factor in the small intestine that mediates acid-stimulated release of secretin in rats.

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confidence: 99%

Pancreatic phospholipase A₂from the small intestine is a secretin-releasing factor in rats

Chang

Wagner

et al. 2001

American Journal of Physiology-Gastrointestinal and Liver Physi

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5-Hydroxytryptamine (5-HT) receptors mediate the release and action of secretin on pancreatic secretion induced by duodenal acidification in rats

Cited by 1 publication

References 0 publications

Pancreatic phospholipase A₂from the small intestine is a secretin-releasing factor in rats

Pancreatic phospholipase A₂from the small intestine is a secretin-releasing factor in rats

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5-Hydroxytryptamine (5-HT) receptors mediate the release and action of secretin on pancreatic secretion induced by duodenal acidification in rats

Cited by 1 publication

References 0 publications

Pancreatic phospholipase A2from the small intestine is a secretin-releasing factor in rats

Pancreatic phospholipase A2from the small intestine is a secretin-releasing factor in rats

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Pancreatic phospholipase A₂from the small intestine is a secretin-releasing factor in rats

Pancreatic phospholipase A₂from the small intestine is a secretin-releasing factor in rats