5-Hydroxychromone, An Alternative Scaffold for Anti-HCV 1,3-Diketo Acid (DKA)

Lee, Chaewoon; Park, Kwang-Su; Park, Hyeri; Park, Jun Cheol; Lee, Bokhui; Kim, Dong-Eun; Chong, Youhoon

doi:10.5012/bkcs.2010.31.11.3471

Cited by 7 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following a drug discovery program 5-hydroxychromones (Figure 23B) were proposed as an interesting scaffold for the development of anti-HCV drugs. 231 Another study showed that a chromone derivative (Figure 23C) exhibit a high activity against hepatitis B virus (HBV) infection and HBV-related liver cancer. 232 Human immunodeficiency virus (HIV) is the causative agent of acquired immune deficiency syndrome (AIDS).…”

Section: Anticancer Drugsmentioning

confidence: 99%

“…Chronic hepatitis C virus (HCV) infection, which affects more than 180 million patients worldwide, is one of the leading causes of cirrhosis and liver failure. Following a drug discovery program 5-hydroxychromones (Figure B) were proposed as an interesting scaffold for the development of anti-HCV drugs . Another study showed that a chromone derivative (Figure C) exhibit a high activity against hepatitis B virus (HBV) infection and HBV-related liver cancer …”

Section: Biological Interest Of Simple Chromonesmentioning

confidence: 99%

See 1 more Smart Citation

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

View full text Add to dashboard Cite

The last few decades have provided stunning progresses in the understanding of physiopathology of several diseases. The remarkable progress in research fields, like genetics, immunology, neurobiology, among others, as well as the advent of more powerful tools, have made it possible to characterize, monitor, and understand far more of the basis of physiology and disease. However, for some diseases the treatment remains a problematic issue as the efforts performed so far were not translated into therapeutic solutions. Notwithstanding the steady increase in the total amount of FCUP

show abstract

Section: Anticancer Drugsmentioning

confidence: 99%

Section: Biological Interest Of Simple Chromonesmentioning

confidence: 99%

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Previously, we discovered a chromone scaffold ( Fig. 1) as a novel pharmacophore for antiviral agents against HCV 4) as well as SARS-CoV, 5) and reported structure-activity relationship studies on a series of chromone derivatives. [6][7][8] Interesting antiviral activities against HCV and/or SARS-CoV were observed from various chromone derivatives.…”

mentioning

confidence: 99%

Design, Synthesis and Antiviral Activity of 2-(3-Amino-4-piperazinylphenyl)chromone Derivatives

Kim

Yoon

Barnard

et al. 2013

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

Previously, we have confirmed that the antiviral activities of the chromone derivatives were controlled by the type as well as the position of the substituents attached to the chromone core structure. In the course of our ongoing efforts to optimize the antiviral activity of the chromone derivatives, we have been attempting to derivatize the chromone scaffold via introduction of various substituents. In this proof-of-concept study, we introduced a 3-amino-4-piperazinylphenyl functionality to the chromone scaffold and evaluated the antiviral activities of the resulting chromone derivatives. The synthesized 2-(3-amino-4-piperazinylphenyl)-chromones showed severe acute respiratory syndrome-corona virus (SARS-CoV)-specific antiviral activity. In particular, the 2-pyridinylpiperazinylphenyl substituents provided the resulting chromone derivatives with selective antiviral activity. Taken together, this result indicates the possible pharmacophoric role of the 2-pyridinylpiperazine functionality attached to the chromone scaffold, which warrants further in-depth structure-activity relationship study.

show abstract

“…Chromones, compounds widely distributed in nature, especially in the plant kingdom play a prominent role in the field of medicine owing to its multifarious pharmacological activity against influenza virus [1] , hepatitis B virus [2] , human rhino virus(HRV) [1] and neuro degenarive diseases [3] . Chromones have been reported to show anti-bacterial, anti-fungal [4] , [5] , anti-cancer [6] , anti-oxidant [7] , anti-HIV [8] and immune-stimulatory [9] activity.…”

Section: Introductionmentioning

confidence: 99%