5-Hydroxy-indolacetic-acid (5-HIAA) serum levels in depressive patients and ECT

Hofmann, Peter; Loimer, Norbert; Chaudhry, H.R.; Pfersmann, D; Schmid, Rainer; Wieselmann, G.

doi:10.1016/0022-3956(96)00015-5

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…Plasma concentrations of 5‐HIAA closely reflect brain concentrations in humans and other mammals 36,37 and 5‐HIAA is an indicator of central monoamine oxidase activity 38 . However, in the present study no relationship was noted between 5‐HIAA and depression scores, a conclusion also reached by Hofmann et al 39 . The absence of any correlation may be the result of different kinetics and metabolism relative to 5‐HT.…”

Section: Discussionsupporting

confidence: 59%

Kynurenine Metabolites and Inflammation Markers in Depressed Patients Treated With Fluoxetine or Counselling

Mackay

Forrest

Christofides

et al. 2009

Clin Exp Pharma Physio

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1. Depression could result from changes in tryptophan availability caused by activation of the kynurenine pathway as a result of inflammation. In the present study, we examined patients newly diagnosed with depression to determine whether kynurenines and related factors change in parallel with improvements in mood. 2. Concentrations of 5-hydroxytryptamine (5-HT; serotonin), 5-hydroxyindoleacetic acid (5-HIAA), oxidized tryptophan metabolites, brain-derived neurotrophic factor (BDNF) and inflammatory mediators (interleukin (IL)-2, C-reactive protein (CRP), neopterin) were measured in peripheral blood during an 18 week period of treatment with fluoxetine, fluoxetine plus tri-iodothyronine (T(3)) or psychiatric counselling. 3. The results showed significant improvements in mood, with reduced 5-HT concentrations in patients given fluoxetine and a rise in plasma tryptophan in patients given counselling or fluoxetine and T(3). The addition of T(3) to the fluoxetine regimen appeared to slow recovery from depression, although the use of T(3) was associated with a fall in thyroxine concentrations. Changes in 5-HT concentrations did not correlate with psychiatric scores and were seen only in drug-treated groups, not those given counselling. There were no associated changes in absolute concentrations of kynurenines, BDNF, CRP, neopterin or IL-2. With fluoxetine treatment, there were correlations between the concentrations of kynurenine metabolites and the psychiatric rating scores, whereas no correlations were found with BDNF or inflammatory markers. 4. It is concluded that depression scores are largely independent of inflammatory status, but kynurenine metabolism may be related to the degree of depression after fluoxetine treatment.

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Section: Discussionsupporting

confidence: 59%

Kynurenine Metabolites and Inflammation Markers in Depressed Patients Treated With Fluoxetine or Counselling

Mackay

Forrest

Christofides

et al. 2009

Clin Exp Pharma Physio

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“…This monoamine is synthesized from its precursor tryptophan and metabolized to 5-hydroxyindoleacetic acid [5]. Several findings on platelet/blood serotonin levels have been reported in various psychiatric, neurological, and immune system disorders [6,7].…”

Section: Introductionmentioning

confidence: 99%

Chondroitin sulfate and kallikrein in saliva: Markers for glossodynia

Loeb

Naffah-Mazzacoratti

Porcionatto

et al. 2008

International Immunopharmacology

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“…38 included studies recruited humans ( Table 2 ) [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ] and 27 studied animal models ( Table 3 ) [ 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ,…”

Section: Resultsmentioning

confidence: 99%

Non-Invasive Brain Stimulation Effects on Biomarkers of Tryptophan Metabolism: A Scoping Review and Meta-Analysis

Giron

Lin

Kan

et al. 2022

IJMS

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Abnormal activation of the kynurenine and serotonin pathways of tryptophan metabolism is linked to a host of neuropsychiatric disorders. Concurrently, noninvasive brain stimulation (NIBS) techniques demonstrate high therapeutic efficacy across neuropsychiatric disorders, with indications for modulated neuroplasticity underlying such effects. We therefore conducted a scoping review with meta-analysis of eligible studies, conforming with the PRISMA statement, by searching the PubMed and Web of Science databases for clinical and preclinical studies that report the effects of NIBS on biomarkers of tryptophan metabolism. NIBS techniques reviewed were electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS). Of the 564 search results, 65 studies were included with publications dating back to 1971 until 2022. The Robust Bayesian Meta-Analysis on clinical studies and qualitative analysis identified general null effects by NIBS on biomarkers of tryptophan metabolism, but moderate evidence for TMS effects on elevating serum serotonin levels. We cannot interpret this as evidence for or against the effects of NIBS on these biomarkers, as there exists several confounding methodological differences in this literature. Future controlled studies are needed to elucidate the effects of NIBS on biomarkers of tryptophan metabolism, an under-investigated question with substantial implications to clinical research and practice.

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5-Hydroxy-indolacetic-acid (5-HIAA) serum levels in depressive patients and ECT

Cited by 10 publications

References 23 publications

Kynurenine Metabolites and Inflammation Markers in Depressed Patients Treated With Fluoxetine or Counselling

Kynurenine Metabolites and Inflammation Markers in Depressed Patients Treated With Fluoxetine or Counselling

Chondroitin sulfate and kallikrein in saliva: Markers for glossodynia

Non-Invasive Brain Stimulation Effects on Biomarkers of Tryptophan Metabolism: A Scoping Review and Meta-Analysis

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