5-HT2A receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study

Messa, Cristina; Colombo, Cristina; Moresco, Rosa María; Gobbo, C.; Galli, Laura; Lucignani, Giovanni; Gilardi, Maria Carla; Rizzo, Giovanna; Smeraldi, Enrico; Zanardi, Raffaella; Artigas, Francesc; Fazio, Ferruccio

doi:10.1007/s00213-002-1379-5

Cited by 92 publications

(60 citation statements)

References 41 publications

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“…However, the involvement of 5-HT 2A receptor binding in major depression has been explored in several cross-sectional postmortem (Stockmeier, 2003) and imaging studies (Attar-Levy et al, 1999;Biver et al, 1997;Yatham et al, 2000;Messa et al, 2003) of which two studies took into account measures of negativistic thinking. A recent study by Bhagwagar et al (2006), in un-medicated, euthymic patients recovered from depression, support that a higher frontolimbic 5-HT 2A receptor level may be a trait factor of the susceptibility to develop depression and correlate positively with measures of negativistic thinking.…”

Section: Discussionmentioning

confidence: 99%

Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding

Frøkjær¹,

Vinberg

Erritzoe³

et al. 2009

Neuropsychopharmacol

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Life stress is a robust risk factor for later development of mood disorders, particularly for individuals at familial risk. Likewise, scoring high on the personality trait neuroticism is associated with an increased risk for mood disorders. Neuroticism partly reflects stress vulnerability and is positively correlated to frontolimbic serotonin 2A (5-HT 2A ) receptor binding. Here, we investigate whether neuroticism interacts with familial risk in relation to frontolimbic 5-HT 2A receptor binding. Twenty-one healthy twins with a co-twin history of mood disorder and 16 healthy twins without a co-twin history of mood disorder were included. They answered self-report personality questionnaires and underwent [ 18 F]altanserin positron emission tomography. We found a significant interaction between neuroticism and familial risk in predicting the frontolimbic 5-HT 2A receptor binding (p ¼ 0.026) in an analysis adjusting for age and body mass index. Within the high-risk group only, neuroticism and frontolimbic 5-HT 2A receptor binding was positively associated (p ¼ 0.0037). In conclusion, our data indicate that familial risk and neuroticism interact in their relation to frontolimbic 5-HT 2A receptor binding. These findings point at a plausible neurobiological link between genetic and personality risk factors and vulnerability to developing mood disorders. It contributes to our understanding of why some people at high risk develop mood disorders while others do not. We speculate that an increased stress reactivity in individuals at high familial risk for mood disorders might enhance the effect of neuroticism in shaping the impact of potential environmental stress and thereby influence serotonergic neurotransmission.

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Section: Discussionmentioning

confidence: 99%

Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding

Frøkjær¹,

Vinberg

Erritzoe³

et al. 2009

Neuropsychopharmacol

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“…Given that our first episode ADN individuals, with a similar subtype of depression, showed no differences in 5-HT 2A BI compared to healthy controls we cannot exclude the possibility that the differences between ADN and TRD group are due to treatment exposure rather than depression itself. However, Messa et al (2003) studied a group of antidepressant naive depressed patients (thus without treatment exposure) who had from 0 to 3 former depressive episodes and they also showed shown that successful treatment response with SSRI and electroconvulsive shock therapy (ECT) was associated with prefrontal 5-HT 2A receptor up-regulation (Massau et al 1997;Burnet et al 1999;Zanardi et al 2001). Another confounding factor could have been the use of benzodiazepines in the TRD patient group.…”

Section: Frontal Cortexmentioning

confidence: 99%

“…Although negative results are also reported (Schins et al 2005), Messa et al (2003) found decreased frontal cortical 5-HT 2A binding indices in symptomatic ADN patients as compared to their control group.…”

mentioning

confidence: 92%

“…Few studies have examined the differences in 5-HT 2A receptor binding between currently depressed antidepressant naïve (ADN) patients, depressed patients who have been treated with antidepressants, and never-depressed healthy controls (Massau et al 1997;Messa et al 2003;Schins et al 2005). Although negative results are also reported (Schins et al 2005), Messa et al (2003) found decreased frontal cortical 5-HT 2A binding indices in symptomatic ADN patients as compared to their control group.…”

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confidence: 99%

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Is treatment-resistance in unipolar melancholic depression characterized by decreased serotonin2A receptors in the dorsal prefrontal – Anterior cingulate cortex?

2012

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Objectives: Quite a number of patients diagnosed with major depression are resistant to several well carried-out psychopharmacological interventions. It remains unclear as to how the serotonergic system is implicated in the phenomenon of treatment-resistance. regulated. However, whether this assumed underlying pathophysiological mechanism is due solely to abnormalities in the serotonergic system remains to be answered.3

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“…In vivo studies in people with major depression have found both reduced (Biver et al, 1997;Attar-Levy et al, 1999;Yatham et al, 2000;Messa et al, 2003) and normal (Meyer et al, 2001) 5-HT 2A receptor binding values. In addition, decreased volume (Hirayasu et al, 1999) and reduced cerebral blood flow and metabolism (Drevets et al, 1997(Drevets et al, , 2002Buchsbaum et al, 1997) have been found in the left subgenual cingulate in depressed subjects relative to controls.…”

Section: Only Rec An Have Reduced [mentioning

confidence: 99%

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

Bailer

Price

Meltzer

et al. 2004

Neuropsychopharmacol

151

107

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Several lines of evidence suggest that a disturbance of serotonin neuronal pathways may contribute to the pathogenesis of anorexia nervosa (AN) and bulimia nervosa (BN). This study applied positron emission tomography (PET) to investigate the brain serotonin 2A (5-HT 2A ) receptor, which could contribute to disturbances of appetite and behavior in AN and BN. To avoid the confounding effects of malnutrition, we studied 10 women recovered from bulimia-type AN (REC AN-BN, 41 year normal weight, regular menstrual cycles, no binging, or purging) compared with 16 healthy control women (CW) using PET imaging and a specific 5-HT 2A 18 F]altanserin binding potential and drive for thinness in several cortical regions. In conclusion, this study extends research suggesting that altered 5-HT neuronal system activity persists after recovery from bulimia-type AN, particularly in subgenual cingulate regions. Altered 5-HT neurotransmission after recovery also supports the possibility that this may be a trait-related disturbance that contributes to the pathophysiology of eating disorders. It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects.

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5-HT2A receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study

Cited by 92 publications

References 41 publications

Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding

Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding

Is treatment-resistance in unipolar melancholic depression characterized by decreased serotonin2A receptors in the dorsal prefrontal – Anterior cingulate cortex?

Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness

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