5-HT1D as well as 5-HT1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphénucleus

Interaction between a selective 5‐HT1Areceptor antagonist and an SSRI in vivo: effects on 5‐HT cell firing and extracellular 5‐HT

“…loss of neurone during recording), the involvement of 5-HT receptors other than the 5-HTlA receptor might be implicated. In this respect it is relevant that, in the guinea-pig, 5-HTIB/D receptors have been shown to modulate 5-HT release in the DRN (Starkey & Skingle, 1994). However, a recent in vitro electrophysiological study suggested that 5-HTlD receptors have no role in the inhibition of firing of DRN 5-HT neurones by exogenous 5-HT (Craven et al, 1994 (Verge et al, 1985;Sotelo et al, 1990), are known to inhibit 5-HT cell firing (Sprouse & Aghajanian, 1987).…”

Evidence that 5‐hydroxytryptamine release in rat dorsal raphé nucleus is controlled by 5‐HT1A, 5‐HT1B and 5‐HT1D autoreceptors

“…Although it is possible that, at this concentration (0.5 AM), sumatriptan has a small effect at the 5-HTIB receptor (pKB = 6.0: Hoyer et al, 1994), the absence of effect of isamoltane makes this unlikely. The 5-HTIE subtype is also unlikely to explain the actions of sumatriptan and GR-127935 since their affinity at this site is at least 2 orders of magnitude lower than at the 5-HTID receptor (Starkey & Skingle, 1994).…”

“…Recently however, studies in the guinea-pig have shown that 5-HTlD autoreceptors can also influence 5-HT release in the DRN (Starkey & Skingle, 1994). The rat homologue of the 5-HTIDp receptor is the 5-HTIB receptor (Hoyer et al, 1994) and we have now shown (Davidson & Stamford, 1994) that 5-HT release in the rat DRN may also be reduced by the 5-HTlB/D agonist, 2,3,5,…”

Inverse Agonists and Serotonergic Transmission From Recombinant, Human Serotonin (5-HT)1B Receptors to G-Protein Coupling and Function in Corticolimbic Structures in vivo

“…For example, core temperature is homeostatically controlled by multiple factors. Further, blockade of dendritic 5-HT 1D (or 5-HT 1B ) sites may increase concentrations of 5-HT at colocalized 5-HT 1A autoreceptors, thereby masking this action (Starkey and Skingle 1994). However, combined administration of WAY100,635 with GR127,935 or SB224,289 for simultaneous blockade of 5-HT 1A and 5-HT 1B/1D autoreceptors also failed to enhance dialysate 5-HT levels.…”

“…The 5-HT 1A , 5-HT 1B , and 5-HT 1D receptors are of particular interest inasmuch as they are localized both postsynaptically to serotonergic neurones as well as presynaptically, as inhibitory autoreceptors on their dendrites (5-HT 1A and a minor population of 5-HT 1B/1D sites) and terminals (5-HT 1B sites) (Piñeyro et al 1995;Starkey and Skingle 1994). It might, thus, be hypothesized that inverse agonist actions at 5-HT 1A , 5-HT 1B , and/or 5-HT 1D autoreceptors may facilitate serotonergic transmission (Gaster et al 1998;Moret and Briley 1993;Roberts et al 1997).…”