5-HT1A receptor gene silencers Freud-1 and Freud-2 are differently expressed in the brain of rats with genetically determined high level of fear-induced aggression or its absence

Кондаурова, Е. М.; Ilchibaeva, Tatiana V.; Цыбко, А. С.; Kozhemyakina, R. V.; Попова, Н. К.; Науменко, В. С.

doi:10.1016/j.bbr.2016.04.050

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…These animals differ in a number of behavioral characteristics: the aggressive rats manifest greater fear [ 31 , 32 ], high anxiety [ 33 ], and a reduction in learning abilities and memory compared with the tame animals [ 34 ]. Moreover, the aggressive and tame rats demonstrate significant alterations in their brain serotonergic and BDNF systems [ 14 , 31 , 35 , 36 , 37 , 38 , 39 , 40 ]. Nonetheless, the function of the noncoding regulatory Bdnf exons in the mechanisms of aggression toward humans and domestication has not been studied yet.…”

Section: Introductionmentioning

confidence: 99%

On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153

Moskaliuk

Kozhemyakina

Khomenko

et al. 2023

IJMS

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The Bdnf (brain-derived neurotrophic factor) gene contains eight regulatory exons (I–VIII) alternatively spliced to the protein-coding exon IX. Only exons I, II, IV, and VI are relatively well studied. The BDNF system and brain serotonergic system are tightly interconnected and associated with aggression. The benzopentathiepine TC-2153 affects both systems and exerts antiaggressive action. Our aim was to evaluate the effects of TC-2153 on the Bdnf exons I–IX’s expressions and serotonin receptors’ mRNA levels in the brain of rats featuring high aggression toward humans (aggressive) or its absence (tame). Aggressive and tame adult male rats were treated once with vehicle or 10 or 20 mg/kg of TC-2153. mRNA was quantified in the cortex, hippocampus, hypothalamus, and midbrain with real-time PCR. Selective breeding for high aggression or its absence affected the serotonin receptors’ and Bdnf exons’ transcripts differentially, depending on the genotype (strain) and brain region. TC-2153 had comprehensive effects on the Bdnf exons’ expressions. The main trend was downregulation in the hypothalamus and midbrain. TC-2153 increased 5-HT1B receptor hypothalamusc mRNA expression. For the first time, an influence of TC-2153 on the expressions of Bdnf regulatory exons and the 5-HT1B receptor was shown, as was an association between Bdnf regulatory exons and fear-induced aggression involving genetic predisposition.

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Section: Introductionmentioning

confidence: 99%

On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153

Moskaliuk

Kozhemyakina

Khomenko

et al. 2023

IJMS

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“…These brainstem 5-HT-producing cells, or source nodes, project to multiple midbrain and forebrain regions, many of which are implicated in social behavior regulation (Kuhar, Roth & Aghajanian, 1971; Lorens & Guldberg, 1974; Hale & Lowry, 2011; Kerman et al, 2011; Kusljic & Van Den Buuse, 2012). Some of these regions, including the amygdala, hippocampus, and nucleus accumbens, have been shown to contain 5-HT receptors and levels of these receptors are predictive of aggression in mice and rats (Nautiyal et al, 2015; Suzuki & Lucas, 2015; Kondaurova et al, 2016). Furthermore, the 5-HT network interacts with other neurotransmitter systems involved in the social behavior network, including dopamine in the striatum, vasopressin in the anterior hypothalamus and medial amygdala, and oxytocin in the raphe nuclei (Messripour & Mesripour, 2013; Morrison & Melloni Jr, 2014; Pagani et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Serotonergic activation during courtship and aggression in the brown anole,Anolis sagrei

Hartline

Smith

Kabelik

2017

PeerJ

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The role of serotonin (5-hydroxytryptamine, 5-HT) in social behavior regulation is not fully understood. While 5-HT release in nuclei of the social behavior network has generally been associated with inhibition of aggressive behavior across multiple classes of vertebrates, less is known about its effects on sexual, especially non-copulatory courtship display behaviors. Furthermore, most research has examined effects at 5-HT release sites, while studies examining the behavioral relevance of source cell populations have generated contradictory findings. This study utilized immunohistochemistry to examine the colocalization of 5-HT with Fos, an immediate early gene product and marker of neural activity, in the raphe and superior reticular nuclei of male brown anoles (Anolis sagrei) exposed to either aggression, courtship, or control social interactions. Supporting previous research, copulation was associated with a decrease in 5-HT activity, while a novel link between 5-HT activity and latency to non-copulatory courtship was also found. Within the aggression group, intensity and frequency of behavior were both associated with decreased 5-HT activity. An effect of social context was also seen, with anoles exposed to either courtship or aggression encounters showing decreased 5-HT activity in certain raphe and superior reticular nuclei populations compared to controls. Interestingly, context effects and behavioral effects were seen at separate brain nuclei, suggesting the presence of separate systems with distinct functional roles.

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On an association between fear-induced aggression and striatal-enriched protein tyrosine phosphatase (STEP) in the brain of Norway rats

Moskaliuk

Kozhemyakina

Базовкина

et al. 2022

Biomedicine & Pharmacotherapy

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5-HT1A receptor gene silencers Freud-1 and Freud-2 are differently expressed in the brain of rats with genetically determined high level of fear-induced aggression or its absence

Cited by 7 publications

References 36 publications

On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153

On Associations between Fear-Induced Aggression, Bdnf Transcripts, and Serotonin Receptors in the Brains of Norway Rats: An Influence of Antiaggressive Drug TC-2153

Serotonergic activation during courtship and aggression in the brown anole,Anolis sagrei

On an association between fear-induced aggression and striatal-enriched protein tyrosine phosphatase (STEP) in the brain of Norway rats

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