5-HT1A receptor blockade targeting the basolateral amygdala improved stress-induced impairment of memory consolidation and retrieval in rats

Sardari, Maryam; Rezayof, Ameneh; Zarrindast, Mohammad‐Reza

doi:10.1016/j.neuroscience.2015.05.031

Cited by 16 publications

(16 citation statements)

References 82 publications

(20 reference statements)

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“…They were similar to those employed in previous studies (see e.g. Cinelli et al., 2014; Johnson, Wilkerson, Henderson, Wenninger, & Mitchell, 2001; Ostrowski, Ostrowski, Hasser, & Kline, 2014; Sardari, Rezayof, & Zarrindast, 2015). In these trials, as in a previous study (Mutolo et al., 2010), control experiments with equivalent amounts of DMSO in the perfusing solution were performed.…”

Section: Methodssupporting

confidence: 88%

Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Cinelli

Mutolo

Iovino

et al. 2020

Eur J of Neuroscience

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In mammals, 5-HTexcitatory respiratory effects imply 5-HT 1A receptor-mediated disinhibition of pre-Bötzinger complex neurons. In the lamprey, 5-HT 1A receptors are involved in the neural control of locomotion, but their role in the respiratory regulation, particularly at the level of the putative respiratory rhythm generator, the paratrigeminal respiratory group (pTRG), is not known. We here investigate the respiratory function of inhibitory 5-HT 1A receptors within the pTRG of the isolated brainstem of the adult lamprey. The 5-HT 1A receptor agonists either bath applied or microinjected into the pTRG did not cause significant effects. However, the selective 5-HT 1A receptor antagonist (S)-WAY 100135 bath applied or microinjected into the pTRG induced depressing respiratory effects or even apnoea, thus revealing that 5-HT exerts a 5-HT 1A receptor-mediated potent tonic influence on respiration and contributes to maintain baseline levels of respiratory activity. Microinjections of strychnine or bicuculline, either alone or in combination, into the pTRG prevented (S)-WAY 100135-induced apnoea. In addition, immunohistochemical studies corroborate the present findings suggesting that 5-HT 1A receptors are widely expressed in close apposition to the soma of glycine-immunoreactive cells located within the pTRG region. The results show that in the lamprey respiratory network, 5-HT exerts a tonic influence on respiration by a potent inhibitory control on both GABAergic and glycinergic mechanisms. The observed disinhibitory effects resemble the excitatory respiratory modulation exerted by 5-HT 1A receptor-mediated inhibition of glycinergic and/or GABAergic neurons present in mammals, supporting the notion 3904 | CINELLI Et aL.

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Section: Methodssupporting

confidence: 88%

Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Cinelli

Mutolo

Iovino

et al. 2020

Eur J of Neuroscience

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“…We previously reported that pre-test acute inescapable stress impaired memory retrieval in passive avoidance task (Sardari et al, 2015).…”

Section: Discussionmentioning

confidence: 96%

Activation of cannabinoid CB1 receptors in the ventral hippocampus improved stress-induced amnesia in rat

2016

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“…Drug concentrations were selected in preliminary trials. They were in the same range as those previously used in in vivo preparations (Merahi and Laguzzi 1995;Sevoz et al, 1996;Comet et al, 2007;Monti et al, 2008;Rauch et al, 2008;Bongianni et al, 2010;Valic et al, 2010;Ostrowski et al, 2014;Zhang et al, 2014;Sardari et al, 2015).…”

Section: Microinjection Procedures and Experimental Protocolmentioning

confidence: 99%

Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit

et al. 2019

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5-HT1A receptor blockade targeting the basolateral amygdala improved stress-induced impairment of memory consolidation and retrieval in rats

Cited by 16 publications

References 82 publications

Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Activation of cannabinoid CB1 receptors in the ventral hippocampus improved stress-induced amnesia in rat

Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit

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5-HT1A receptor blockade targeting the basolateral amygdala improved stress-induced impairment of memory consolidation and retrieval in rats

Cited by 16 publications

References 82 publications

Key role of 5‐HT1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Key role of 5‐HT1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Activation of cannabinoid CB1 receptors in the ventral hippocampus improved stress-induced amnesia in rat

Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit

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Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys

Key role of 5‐HT_1A receptors in the modulation of the neuronal network underlying the respiratory rhythm generation in lampreys