5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward

Montgomery, A. M. J.; Röse, I; Herberg, L.J.

doi:10.1007/bf01244460

Cited by 49 publications

(24 citation statements)

References 45 publications

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“…By contrast, administration of the 5-HTlc/~ D agonist, m-CPP, interfered with copulation and resulted in the monkeys mounting at a slower rate and taking a longer period of time to ejaculate. The biphasic dose-response pattern of monkeys following treatment with 8-OH-DPAT, in which low doses but not high doses of 8-OH-DPAT facilitated ejaculation, resembles similar biphasic dose-response effects of 8-OH-DPAT that have been observed for a number of behaviors in rats including feeding (Dourish et al 1985), place conditioning (Papp and Willner 1991), anti-conflict responding (Engel et al 1984;Soderpalm et al 1989), thermoregulation (Goodwin et al 1987) and rewarding electrical brain stimulation (Montgomery et at. 1991).…”

Section: Discussionmentioning

confidence: 69%

Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists

1993

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Although numerous studies in rats have demonstrated an influence of serotonin (5-HT) on male copulation, no studies have yet to demonstrate whether such a relationship exists in primate species. The present study sought to characterize 5-HT influences on male copulatory behavior of rhesus monkeys by using three different 5-HT agonists: a full 5-HT1A agonist, 8-hydroxy-2-(din-propylamino) tetralin (8-OH-DPAT); a partial 5-HT1A agonist, ipsapirone; and a 5-HT 1C/ID agonist, m-chlorophenylpiperazine (m-CPP). 8-OH-DPAT had a biphasic effect upon ejaculation latency, with low doses (5-10 micrograms/kg) producing a shortening of ejaculation latency (time from initiation of copulation to ejaculation), and the highest dose (100 micrograms/kg) producing a lengthening of ejaculation latency. Intromission frequency (number of intromissions preceding ejaculation) was affected only at 10 micrograms/kg 8-OH-DPAT with monkeys requiring fewer intromissions to ejaculation at this dose. Ipsapirone administration led to a shortening of ejaculation latency at all doses tested (50-800 micrograms/kg), and a reduction in intromission frequency at 200-800 micrograms/kg ipsapirone. Administration of the 5-HT 1C/1D agonist, m-CPP, resulted in an increase in ejaculation latency at 200-400 micrograms/kg m-CPP and mount latency at 400 micrograms/kg m-CPP, but did not affect intromission frequency. In summary, stimulation of 5-HT1A receptors lowered the ejaculatory threshold of the monkeys, while stimulation of 5-HT 1C/1D receptors interfered with copulatory behavior and raised the ejaculatory threshold.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 69%

Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists

1993

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“…Interestingly, antidepressants and dopamine agonists (e.g., tricyclics), affect selfstimulation behavior in rodents (20,27). Serotonergic mechanisms are also probably involved in influencing self-stimulation behavior resulting from interactions with the dopaminergic system (26).…”

Section: Discussionmentioning

confidence: 99%

Cytokine mediation of experimental heart failure-induced anhedonia

Grippo

Francis

Weiß

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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Immune system dysfunction is hypothesized to influence several disease states, including cardiovascular disease and psychological depression. The comorbidity of depression and coronary artery disease may be influenced by immune system-brain interactions involving proinflammatory cytokines. The present studies evaluated an index of depression in a rodent model of heart failure by measuring responses to rewarding electrical brain stimulation, which provides an experimental procedure to operationally define anhedonia in rats. Heart failure led to a rightward shift in the current-response relationship in the brain stimulation paradigm, indicative of reduced rewarding properties of the brain stimulation (i.e., anhedonia). Acute treatment with a tumor necrosis factor antagonist, etanercept, reduced circulating tumor necrosis factor-α levels in rats with heart failure and restored responding for electrical brain stimulation. The current findings have implications for the study of pathophysiological mechanisms underlying the association of cardiovascular disease and depression.

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“…These behaviors are under the control of mesoaccumbens DA activity (for review, see Di Chiara, 1995) and can be enhanced or inhibited by decreasing or increasing, respectively, 5-HT neurotransmission [electrical brain stimulation (Poschel and Ninteman, 1971;Katz and Carroll, 1977;Montgomery et al, 1991;Olds and Yuwiler, 1992;Fletcher et al, 1995) and intravenous drug self-administration (Carroll et al, 1990a,b;Loh and Roberts, 1990;Richardson and Roberts, 1991)]. There is, however, a recent report showing that stimulation of the 5-HT 1B receptor subtype may actually enhance cocaine reinforcement and thus cocaine self-administration behavior (Parsons et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Lateral Hypothalamic Serotonin Inhibits Nucleus Accumbens Dopamine: Implications for Sexual Satiety

et al. 1999

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Dopamine (DA) is released in several brain areas, including the nucleus accumbens (NAcc), before and during copulation in male rats. DA agonists administered into this area facilitate, and DA antagonists inhibit, numerous motivated behaviors, including male sexual behavior. Serotonin (5-HT) is generally inhibitory to male sexual behavior. We reported previously that 5-HT is released in the anterior lateral hypothalamic area (LHA A ) and that a selective serotonin reuptake inhibitor microinjected into that area delayed and slowed copulation. Our present results, using high temporal resolution microdialysis, (1) confirm previous electrochemical evidence that extracellular levels of DA increase in the NAcc during copulation and decrease during the postejaculatory interval (PEI) and (2) reveal that LHA A 5-HT can inhibit both basal and female-elicited DA release in the NAcc. These findings suggest that the neural circuit promoting sexual quiescence during the PEI includes serotonergic input to the LHA A , which in turn inhibits DA release in the NAcc. These findings may also provide insights concerning the inhibitory control of other motivated behaviors activated by the NAcc and may have relevance for understanding the sexual side effects common to antidepressant medications.

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5-HT1A agonists and dopamine: the effects of 8-OH-DPAT and buspirone on brain-stimulation reward

Cited by 49 publications

References 45 publications

Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists

Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists

Cytokine mediation of experimental heart failure-induced anhedonia

Lateral Hypothalamic Serotonin Inhibits Nucleus Accumbens Dopamine: Implications for Sexual Satiety

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