5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: Role of dorsal raphe nucleus

Freitas, Renato Leonardo de; Ferreira, César Augusto; Urbina, M; Marino, A; Carvalho, A.D.; Butera, G.; Oliveira, Ana Maria de; Coimbra, Norberto Cysne

doi:10.1016/j.expneurol.2009.01.003

Cited by 37 publications

(38 citation statements)

References 49 publications

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“…It was thus concluded that the 5-CT effect was mediated by the 5-HT 7 receptor (Pericic & Svob Strac, 2007). Finally, it has been suggested that the 5-HT 7 receptor is involved in regulating tonic-clonic seizure-induced antinociception (Freitas et al, 2009). …”

Section: 5-ht7 Receptor Function In Normal and Pathological Processesmentioning

confidence: 99%

“…The effect was observed for pain behaviors organized at the medullary and forebrain levels, but not at the spinal level, of the neuraxis (Harte et al, 2005). As noted above, in a possible link between 5-HT 7 receptors, epilepsy, and pain modulation it has been suggested that 5-HT 7 receptors are involved in regulating tonic-clonic seizure-induced antinociception (Freitas et al, 2009). Taken together, available data appear to suggest differing roles for the 5-HT 7 receptor in peripheral versus central pain mediation.…”

Section: 5-ht7 Receptor Function In Normal and Pathological Processesmentioning

confidence: 99%

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Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders

Leopoldo

Lacivita

Berardi

et al. 2011

Pharmacology & Therapeutics

159

145

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Since its discovery in the 1940s in serum, the mammalian intestinal mucosa, and in the central nervous system, serotonin (5-HT) has been shown to be involved in virtually all cognitive and behavioral human functions, and alterations in its neurochemistry have been implicated in the etiology of a plethora of neuropsychiatric disorders. The cloning of 5-HT receptor subtypes has been of importance in enabling them to be classified as specific protein molecules encoded by specific genes. The 5-HT7 receptor is the most recently classified member of the serotonin receptor family. Since its identification, it has been the subject of intense research efforts driven by its presence in functionally relevant regions of the brain. The availability of some selective antagonists and agonists, in combination with genetically modified mice lacking the 5-HT7 receptor, has allowed for a better understanding of the pathophysiological role of this receptor. This paper reviews data on localization and pharmacological properties of the 5-HT7 receptor, and summarizes the results of structure-activity relationship studies aimed at the discovery of selective 5-HT7 receptor ligands. Additionally, an overview of the potential therapeutic applications of 5-HT7 receptor agonists and antagonists in central nervous system disorders is presented.

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Section: 5-ht7 Receptor Function In Normal and Pathological Processesmentioning

confidence: 99%

Section: 5-ht7 Receptor Function In Normal and Pathological Processesmentioning

confidence: 99%

Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders

Leopoldo

Lacivita

Berardi

et al. 2011

Pharmacology & Therapeutics

159

145

View full text Add to dashboard Cite

show abstract

“…The effect was observed for pain behaviors organized at the medullary and forebrain levels, but not at the spinal level, of the neuraxis (Harte et al 2005). In a possible link between 5-HT 7 receptors, epilepsy, and pain modulation it has been suggested that 5-HT 7 receptors are involved in regulating tonic-clonic seizure-induced antinociception (Freitas et al 2009). Taken together, available data appear to suggest differing roles for the 5-HT 7 receptor in peripheral versus central pain mediation.…”

Section: Painmentioning

confidence: 99%

The 5-HT7 receptor and disorders of the nervous system: an overview

2009

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Rationale The 5-HT7 receptor is a more recently discovered G-protein-coupled receptor for serotonin. The functions and possible clinical relevance of this receptor are not yet fully understood. Objective The present paper reviews to what extent the use of animal models of human psychiatric and neurological disorders have implicated the 5-HT7 receptor in such disorders. The studies have used a combination of pharmacological and genetic tools targeting the receptor to evaluate effects on behavior. Results Models of anxiety and schizophrenia have yielded mixed results with no clear role for the 5-HT7 receptor described in these disorders. Some data are available for epilepsy, migraine, and pain but it is still very early to draw any definitive conclusions. There is a considerable amount of evidence supporting a role for the 5-HT7 receptor in depression. Both blockade and inactivation of the receptor have resulted in an antidepressant-like profile in models of depression. Supporting evidence has also been obtained in sleep studies. Especially interesting are the augmented effects achieved by combining antidepressants and 5-HT7 receptor antagonists. The antidepressant effect of amisulpride has been shown to most likely be mediated by the 5-HT7 receptor. Conclusions The use of pharmacological and genetic tools in preclinical animal models strongly supports a role for the 5-HT7 receptor in depression. Indirect evidence exists showing that 5-HT7 receptor antagonism is clinically useful in the treatment of depression. Available data also indicate a possible involvement of the 5-HT7 receptor in anxiety, epilepsy, pain, and schizophrenia.

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“…Henceforth, efforts have been made to elucidate the impact of 5HT 2A/2C receptors in the organization of postictal antinociception [13,16,34,35] and the recruitment of 5-HT 1A/1B , 5-HT 6 , 5-HT 7 receptor subtypes has been demonstrated [36].…”

Section: Discussionmentioning

confidence: 99%

Ictal analgesia in temporal lobe epilepsy – The mechanism of seizure-related burns

et al. 2015

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5-HT1A/1B, 5-HT6, and 5-HT7 serotonergic receptors recruitment in tonic-clonic seizure-induced antinociception: Role of dorsal raphe nucleus

Cited by 37 publications

References 49 publications

Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders

Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders

The 5-HT7 receptor and disorders of the nervous system: an overview

Ictal analgesia in temporal lobe epilepsy – The mechanism of seizure-related burns

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