“…5-HT 3 , the only 5-HT based ligand-gated ion channel, acts via changes in cation currents (e.g., Na + , Ca 2+ ) ( Masson et al, 2012 ). Numerous studies have associated 5-HT 3 mediated drugs with the accumulation of specific proteins found in AD ( Fakhfouri et al, 2019 ; Huang et al, 2020 ; Skovgård et al, 2018 ). For example, in a rat model of AD, a study showed a protective response of a drug, tropisetron, a 5-HT 3 receptor antagonist, on Aβ-induced neurotoxicity on neurons in the hippocampus, a brain region associated with cognitive functions such as memory and spatial navigation ( Rahimian et al, 2013 ).…”