5-HT Receptor Modulators for Therapeutic Use in the Treatment of Obsessive-Compulsive Disorder and Other Psychological Disorders

Abstract

Obsessive-compulsive disorder and mental disordersBiological Target. Serotonin receptor (SR) Summary. Obsessive-compulsive disorder (OCD) is one of the most prevalent neuropsychiatric disorders, affecting 1−3% of the population in the United States. It significantly interferes with quality of life, which leads to disability, functional impairments, financial difficulties, and increased use of health care services (https://www.nimh.nih.gov/health/statistics/ obsessive-compulsive-disorder-ocd, accessed 03/19/2022). A core symptom of obsessive-compulsive disorder (OCD) is obsessions, which can be distressing, unwanted, and uncontrollable thoughts. Sufferers typically fall into several categories: "Washers" are obsessed with contamination and have handwashing and cleaning compulsions, whereas "checkers" are