5-HT induces temporomandibular joint nociception in rats through the local release of inflammatory mediators and activation of local β adrenoceptors

Oliveira, Maria Cláudia G.; Clemente-Napimoga, Juliana Trindade; Teixeira, Juliana Maia; Torres-Chávez, Karla Elena; Parada, Carlos Amílcar; Tambeli, Cláudia Herrera

doi:10.1016/j.pbb.2012.06.005

Cited by 19 publications

(13 citation statements)

References 61 publications

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“…In patients with myofascial TMD, it has been claimed that there is also reduced blood circulation locally [2,32], leading to the inhibition of the reuptake of the algesic substances, which further strengthens the theory that myofascial TMD patients have higher 5-HT levels. The higher levels of 5-HT may indicate that TMD is caused by inflammatory mediators, as it has been reported that 5-HT induces temporomandibular joint nociception by the local release of sympathetic amines and prostaglandins [33].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Microdialysis Catheter Insertion on Glutamate and Serotonin Levels in Masseter Muscle in Patients with Myofascial Temporomandibular Disorders and Healthy Controls

et al. 2019

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Myofascial temporomandibular disorders (TMD) are the most common cause of chronic pain in the orofacial region. Microdialysis has been used to study metabolic changes in the human masseter muscle. The insertion of the microdialysis probe causes acute tissue trauma that could affect the metabolic milieu and thereby influence the results when comparing healthy subjects to those with TMD. This study aimed to investigate the levels of serotonin and glutamate during the acute tissue trauma period in healthy subjects and in patients with TMD. Microdialysis was carried out in 15 patients with TMD and 15 controls, and samples were collected every 20 min during a period of 140 min. No significant alterations of serotonin or glutamate were observed over the 2 h period for the healthy subjects. For the TMD group, a significant decrease in serotonin was observed over time (p < 0.001), followed by a significant increase between 120 and 140 min (p < 0.001). For glutamate, a significant reduction was observed at 40 min compared to baseline. The results showed that there was a spontaneous increase of serotonin 2 h after the insertion of the catheter in patients with TMD. In conclusion, the results showed that there are differences in the masseter muscle levels of serotonin and glutamate during acute nociception in patients with myofascial TMD compared to healthy subjects.

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Section: Discussionmentioning

confidence: 99%

The Effect of Microdialysis Catheter Insertion on Glutamate and Serotonin Levels in Masseter Muscle in Patients with Myofascial Temporomandibular Disorders and Healthy Controls

et al. 2019

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“…In TMJ inflammatory pain models, local sympathomimetic amines contribute to the inflammatory TMJ hyperalgesia by activating β 2 -adrenoceptors, 25 – 27 since β 2 -adrenoceptor antagonist or the depletion of NE in the sympathetic terminals can reverse this effect. 25 , 26 These results suggest that inflammation may sensitize nociceptors to NE and/or increase the release of the sympathetic amines. Furthermore, there is a study showing that α 1 -adrenoceptor upregulation in the dorsal root ganglion (DRG) after spinal nerve ligation may play an important role in the development of adrenergic sensitivity in injured sensory neurons.…”

Section: Possible Sympathetic Mechanisms In Orofacial Painmentioning

confidence: 93%

Peripheral sympathetic mechanisms in orofacial pain

Fan¹,

Zhu²,

He³

et al. 2018

JPR

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Sympathetic nervous system (SNS) is a part of the autonomic nervous system which involuntarily regulates internal body functions. It appears to modulate the processing of nociceptive information. Many orofacial pain conditions involve inflammation of orofacial tissues and/or injury of nerve, some of which might be attributed to SNS. Thus, the aim of this review was to bring together the data available regarding the peripheral sympathetic mechanisms involved in orofacial pain. A clearer understanding of SNS–sensory interactions in orofacial pain may provide a basis for novel therapeutic strategies for conditions that respond poorly to conventional treatments.

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“…Capsaicin, as a derivative from red pepper, binds to transient receptor potential cation channel subfamily V member 1 (TRPV1) to activate sensory terminals and stimulate burning pain after injection (Ribeiro et al, 2020). The nociception induced by serotonin is realized in a rather indirect way on primary neurons via the activation of sympathomimetic amines and the synthesis of prostaglandin (Ribeiro et al, 2020;Oliveira-Fusaro et al, 2012). Zymosan, a polysaccharide derived from yeast cell walls, could induce severe and erosive arthritis and severe pain once injected (do Val et al, 2014).…”

Section: Bioactive Compounds In Preclinical Studiesmentioning

confidence: 99%

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

Cai

et al. 2021

Front. Pharmacol.

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Temporomandibular joint disorders (TMD) are a common health condition caused by the structural or functional disorders of masticatory muscles and the temporomandibular joint (TMJ). Abnormal mandibular movement in TMD patients may cause pain, chronic inflammation, and other discomfort, which could be relieved by a variety of drugs through various delivery systems. In this study, we summarized commonly used therapeutic agents in the management of TMD as well as novel bioactive molecules in preclinical stage and clinical trials. The emerging therapy strategies such as novel intra-TMJ delivery systems and implants based on tissue engineering are also discussed. This comprehensive review will strengthen our understanding of pharmacological approaches for TMD therapy.

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5-HT induces temporomandibular joint nociception in rats through the local release of inflammatory mediators and activation of local β adrenoceptors

Cited by 19 publications

References 61 publications

The Effect of Microdialysis Catheter Insertion on Glutamate and Serotonin Levels in Masseter Muscle in Patients with Myofascial Temporomandibular Disorders and Healthy Controls

The Effect of Microdialysis Catheter Insertion on Glutamate and Serotonin Levels in Masseter Muscle in Patients with Myofascial Temporomandibular Disorders and Healthy Controls

Peripheral sympathetic mechanisms in orofacial pain

Therapeutic Agents for the Treatment of Temporomandibular Joint Disorders: Progress and Perspective

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