5. Hepatic Metabolism of Medium Chain Fatty Acids

Scheig, Robert; Senior, John R.

doi:10.9783/9781512807257-007

Cited by 52 publications

(14 citation statements)

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“…Generally it is well known that the MCT-derived fatty acids are transported via portal vein (7)(8)(9) to the liver, where they are extensively oxidized into CO2 and other water-soluble metabolites such as ketones, and are not incorporated into hepatic lipids or adipose tissues to any appreciable extents (10,11). So, even if MCFAs themselves are not incorporated into the body fat, it can be thought that a part of oxidative aqueous products other than CO2 reach the systemic circulation and are utilized by various organs, including biosynthesis of long chain triglycerides in adipose tissues.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to the LCT which are absorbed via the lymphatic system and are carnitine dependent for penetration into hepatic inner mitochondrial membranes , MCT are absorbed via portal vein system and are not carnitine dependent (7)(8)(9). Whereas conventional fats and oils are slowly absorbed and metabolized and utilized as fuel or deposited as body fat, MCT are absorbed and metabolized rapidly into CO2 or ketone body (10,11) and used as energy with little tendency to deposit.…”

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confidence: 99%

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The Influence of Dietary Medium and Long Chain Triglycerides on Growth Performances and Fat Deposition in Growing Rats.

Hwang

Yano

Kawashima

1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe present study was undertaken to investigate the effects of dietary medium and long chain triglycerides (MCT and LCT) on fat deposition and fatty acid composition of adipose tissues of rats. Twen ty-seven Wistar strain male rats were divided into three groups and fed semisynthetic experimental diets: Basal (AIN 76), MCT (basal+C8:0 10%), LCT (basal+corn oil 10%). Feed intake was measured every day and body weight was measured once a week. At the beginning, 4th and 8 th week of experimental feeding, 3, 12, 12 rats were slaughtered, re spectively. Liver, perirenal and epididymal adipose tissue pads were weighed and their fatty acid composition was determined. Chemical composition of wholebody carcass was measured. Body weight gain was greater in rats fed the LCT diet than in rats fed the basal and MCT diets. Feed intakes were decreased in rats fed the MCT and LCT diets compared to that of the basal group. Subsequently, when compared to the basal group rats, feed efficiencies in rats fed the MCT and LCT diets were improved at the level of 6 and 14% for 4 weeks, and then 17 and 24% for 8 weeks, respectively. The weight of perirenal and epididymal adipose tissue pads tended to be larger in rats fed the MCT and LCT diets than in the basal group, although not significant. There were not significant di ff erences in wholebody composition among the three groups. But it appeared that in rats fed the MCT diet, moisture content tended to be decreased and crude protein content increased compared to the LCT group rats. Fatty acid composition of the rats fed the LCT diet showed a good reflection of dietary fatty acid composition. Unlike LCT, little of medium chain fatty acid (MCFA) itself were incorporated into liver or adipose tissues. However, it seems that fat deposition of the MCT group was accomplished not by incorporation of dietary fatty acids but by de novo fatty acids synthesis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

The Influence of Dietary Medium and Long Chain Triglycerides on Growth Performances and Fat Deposition in Growing Rats.

Hwang

Yano

Kawashima

1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…They are also referred to as a readily available source of energy, implying a rapid and almost complete oxidation of MCT (15,20,21). Even the existence of an obligatory oxidation of MCFA with increased heat production has been suggested (22,23).…”

Section: Resultsmentioning

confidence: 99%

Quantisation of Oxidation of Medium-Chain Triglycerides in Preterm Infants1

1989

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ABSTRACT. Medium-chain triglycerides, with a chain length of eight and 10 carbon atoms, form up to 50% of the total fat content in some preterm infant formulas. In 20 small preterm infants (birthwt: 1153 f 227 g; mean 2 SD) fed a special formula containing 40% MCT, a primed constant oral infusion study of l-'3C-potassium octanoate was conducted to quantify the oxidation of MCT. A plateau in 13C enrichment in breath COz was reached in all patients within 1-3 h. Simultaneously, substrate utilization was measured using a closed system indirect calorimeter. No significant difference was found between appropriate for gestational age (n = 8) and small for gestational age (n = 12) infants in the percentage of the administered tracer that was oxidized (44.9 f 9

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“…Consumption of MCT's alone results in their absorption into the portal circulation resulting in a high level of first pass hepatic metabolism, whereas long chain triglycerides are absorbed and transported via the lymph entering the circulation prior to liver metabolism. Delivery to muscle tissue is increased where MCFA are oxidized preferentially over LCFA (75). In this study, we attempted to shift energy utilization away from muscle glycogen or protein and allow MCFA to be delivered via the structured lipid and utilized as a muscle energy source.…”

Section: Structured Lipidsmentioning

confidence: 99%