5-grass-pollen SLIT effectiveness in seasonal allergic rhinitis: Impact of sensitization to subtropical grass pollen

Nunen, Sheryl van; Burk, Melanie; Burton, Pamela; Ford, Geoffrey; Harvey, Richard J.; Lozynsky, Alexander; Pickford, Elizabeth; Rimmer, Janet; Smart, Joanne; Sutherland, Michael; Thien, Francis; Weber, Heinrich C.; Zehnwirth, Harry; Newbigin, Ed; Katelaris, Constance H.

doi:10.1016/j.waojou.2022.100632

Cited by 2 publications

(3 citation statements)

References 28 publications

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“… 70 Improvements in total symptom scores were observed in both monoallergic and polysensitized patients in the first pollen season, with these improvements sustained over the second and third pollen seasons. 70 …”

Section: Efficacy and Safety Of Oralair® In Allergic Rhinitismentioning

confidence: 96%

“…In total, 74.6% were polysensitized to subtropical and temperate grass pollen, and 23.8% monoallergic to temperate grass pollen. 70 Improvements in total symptom scores were observed in both monoallergic and polysensitized patients in the first pollen season, with these improvements sustained over the second and third pollen seasons. 70 …”

Section: Efficacy and Safety Of Oralair® In Allergic Rhinitismentioning

confidence: 96%

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Update about Oralair® as a treatment for grass pollen allergic rhinitis

Klimek

Mösges

Demoly

et al. 2022

Human Vaccines & Immunotherapeutics

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Sublingual immunotherapy (SLIT) is a well-tolerated, safe, and effective approach to treating allergic rhinitis (AR). Oralair® is a five-grass pollen SLIT tablet containing natural pollen allergens from five of the major grass species responsible for seasonal AR due to grass pollen allergy. Recommended use is in a pre-coseasonal regimen, starting daily treatment approximately 4 months before the start of the pollen season, with treatment then continued daily throughout the season; treatment should continue for 3–5 y. Clinical efficacy and safety of Oralair® in patients with grass pollen-induced AR has been demonstrated in a comprehensive clinical development program of randomized controlled trials. Effectiveness has been substantiated in subsequent observational studies with sustained efficacy following treatment cessation and a favorable level of adherence, quality of life, benefit, and satisfaction for the patients. Supportive evidence for a benefit in reducing the risk or delaying the development of allergic asthma is emerging.

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Section: Efficacy and Safety Of Oralair® In Allergic Rhinitismentioning

confidence: 96%

Section: Efficacy and Safety Of Oralair® In Allergic Rhinitismentioning

confidence: 96%

Update about Oralair® as a treatment for grass pollen allergic rhinitis

Klimek

Mösges

Demoly

et al. 2022

Human Vaccines & Immunotherapeutics

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“…Grass and weed pollen plays a key role as a major driver of allergic sensitization, with studies indicating that they are among the most common sources of AR, especially seasonal AR (SAR) ( 7 , 8 ). These types of pollen are prevalent year-round in many parts of the world, especially in Southeast Asia, including Thailand ( 9 , 10 ).…”

Section: Introductionmentioning

confidence: 99%

Incidence of grass and weed sensitization in Bangkok, Thailand: a clinical study

Aud-in,

Juprasong,

Pinkaew

et al. 2024

Front. Public Health

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BackgroundAllergic rhinitis (AR) is a prevalent public health concern globally, significantly impacting quality of life. In Thailand, the prevalence of AR is rising, with grass and weed pollen identified as primary outdoor triggers.ObjectivesThis study aimed to (1) assess patterns of pollen sensitization in Thai AR patients and (2) investigate correlations between demographics/clinical data and SPT results.MethodsA total of 121 individuals aged ≥18 years with clinically diagnosed AR were recruited. Skin prick testing (SPT) was performed using a panel of commonly encountered tropical grass and weed pollen extracts. SPT wheal sizes and clinical symptom scores were recorded. Correlations between SPT outcomes and symptom scores were analyzed.ResultsAmong the participants, 104 (85.95%) exhibited positive SPT reactions to at least one pollen type. Nutsedge (76/121), para grass (57/121), and Bermuda grass (48/121) were the most frequently identified allergens. Hurricane grass elicited the strongest reaction, evidenced by the highest average wheal size (6.2 mm). Poly-sensitization was observed in 77 (63.6%) of the SPT-positive individuals, with most cases involving two different pollen extracts (35/77). Notably, AR severity positively correlated with both average wheal size and the number of positive SPT tests.ConclusionThis study highlights nutsedge, para grass, and Bermuda grass as major allergenic pollen sources for Thai AR patients. Including nutsedge, hurricane grass, and careless weed in clinical SPT panels is recommended for improved diagnostic accuracy. Additionally, the positive correlation between AR severity and pollen reaction strength emphasizes the importance of implementing patient education and avoidance strategies.

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5-grass-pollen SLIT effectiveness in seasonal allergic rhinitis: Impact of sensitization to subtropical grass pollen

Cited by 2 publications

References 28 publications

Update about Oralair® as a treatment for grass pollen allergic rhinitis

Update about Oralair® as a treatment for grass pollen allergic rhinitis

Incidence of grass and weed sensitization in Bangkok, Thailand: a clinical study

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