5-Fluorouracil-containing inorganic iron oxide/platinum nanozymes with dual drug delivery and enzyme-like activity for the treatment of breast cancer

Zheng, Na; Vahdani, Yasaman; Cho, William C.; Bloukh, Samir Haj; Edis, Zehra; Haghighat, Setareh; Falahati, Mojtaba; Kheradmandi, Rasoul; Jaragh-Alhadad, Laila A.; Sharifi, Majid

doi:10.1016/j.arabjc.2022.103966

Cited by 22 publications

(9 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this respect, IONzymes can be used effectively to mimic natural enzymes and applied in several environmental applications, such as degradation of antibiotics and adsorption of dyes, in the food industry and biomedical, biosensing, cosmetics, and bioengineering. [25][26][27][28][29][30][31][32] In this review, we highlight the methods for the synthesis of IONzymes and the current advances in the development of their applications. We discuss several nanomaterials that have been studied to imitate various types of enzymes in order to highlight the advancement in the area of nanomaterial-based articial enzymes.…”

Section: Rana Saidmentioning

confidence: 99%

Magnetic iron oxide-based nanozymes: from synthesis to application

Ghazzy,

Nsairat,

Said

et al. 2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

Section: Rana Saidmentioning

confidence: 99%

Magnetic iron oxide-based nanozymes: from synthesis to application

Ghazzy,

Nsairat,

Said

et al. 2024

Nanoscale Adv.

View full text Add to dashboard Cite

show abstract

“…A list of different types of nanozyme‐mediated cancer therapies classified according to the parent enzyme type is presented in Table 1 . [ 19–43 ] The oxidoreductases mimicking nanozymes that have been explored for their use in cancer therapy include the enzymes POD, OXD, CAT, and SOD as shown in Figure 1. Nanozymes’ enzymatic activities can often be controlled through modulation of the pH, temperature, light, magnetic field, or other external stimuli, which can render them more effective in cancer treatment.…”

Section: Different Types Of Nanozymes and Their Modes Of Operationmentioning

confidence: 99%

“…Female Kunming mice with U14 tumor cells [23] IrO 2 @MSN@PDA-BSA(Ce6) Combined PDT and PTT HT29 cells with BALB/c mice [24] Dox@MOF-Au-PEG Radiochemotherapy U87MG tumor-bearing nude mice [25] PCN-224-Pt PDT H22 tumor-bearing mice [26] PLGA/DOX@PDA-Au-PEG NPs Chemo-photothermal therapy BALB/c mice bearing subcutaneous 4T1 tumors [27] Pd@TiO 2 PDT and PTT 4T1 tumor-bearing mice [28] Fe 3 O 4 /Pt-FLU@PEG Catalytic tumor therapy 4T1 tumor-bearing mice [29] POD-like activity CuS/HSA-TAPP Sonodynamic therapy (SDT) and PTT MCF-7 tumor-bearing BALB/c mice [30] MnPcNPs Catalytic tumor therapy HeLa tumor-bearing mouse model [31] GQD-SPNs Catalytic tumor therapy HeLa tumor-bearing mouse model [32] BSA-capped F-BSP NCs Phototherapy Mice with HeLa cells [33] SnFe 2 O 4 PTT, PDT, and chemodynamic therapy (CDT)…”

Section: Introductionmentioning

confidence: 99%

Smart Nanozymes for Cancer Therapy: The Next Frontier in Oncology

Mehla

Begum

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Nanomaterials that mimic the catalytic activity of natural enzymes in the complex biological environment of the human body are called nanozymes. Recently, nanozyme systems have been reported with diagnostic, imaging, and/or therapeutic capabilities. Smart nanozymes strategically exploit the tumor microenvironment (TME) by the in situ generation of reactive species or by the modulation of the TME itself to result in effective cancer therapy. This topical review focuses on such smart nanozymes for cancer diagnosis, and therapy modalities with enhanced therapeutic effects. The dominant factors that guide the rational design and synthesis of nanozymes for cancer therapy include an understanding of the dynamic TME, structure‐activity relationships, surface chemistry for imparting selectivity, and site‐specific therapy, and stimulus‐responsive modulation of nanozyme activity. This article presents a comprehensive analysis of the subject including the diverse catalytic mechanisms of different types of nanozyme systems, an overview of the TME, cancer diagnosis, and synergistic cancer therapies. The strategic application of nanozymes in cancer treatment can well be a game changer in future oncology. Moreover, recent developments may pave the way for the deployment of nanozyme therapy into other complex healthcare challenges, such as genetic diseases, immune disorders, and ageing.

show abstract

“…The results showed that the obtained nanocomplex can promote cellular uptake and cytotoxicity of nanoparticles loaded with doxorubicin, while the IC 50 of Tat-FeAgNP-Dox was 0.63 µmol·L −1 . Nie et al [ 121 ] fabricated platinum (Pt) nanozymes dispersed on the surface of iron oxide (Fe 3 O 4 ) nanospheres loaded with 5-fluorouracil (FLU), which, in addition to enhancing peroxidase-mimic activity and catalsimic activity, led to the formation of a pH-sensitive nanoplatform for drug delivery for breast cancer treatment. Cytotoxicity tests showed that the obtained Fe 3 O 4 /Pt-FLU@PEG nanospheres moderate the proliferation of 4T1 cancer cells mediated by apoptosis and intracellular production of reactive oxygen species.…”

Section: Synthetic Magnetic Nanoparticlesmentioning

confidence: 99%

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

et al. 2022

View full text Add to dashboard Cite

Magnetic nanocarriers have attracted attention in translational oncology due to their ability to be employed both for tumor diagnostics and therapy. This review summarizes data on applications of synthetic and biogenic magnetic nanoparticles (MNPs) in oncological theranostics and related areas. The basics of both types of MNPs including synthesis approaches, structure, and physicochemical properties are discussed. The properties of synthetic MNPs and biogenic MNPs are compared with regard to their antitumor therapeutic efficiency, diagnostic potential, biocompatibility, and cellular toxicity. The comparative analysis demonstrates that both synthetic and biogenic MNPs could be efficiently used for cancer theranostics, including biosensorics and drug delivery. At the same time, reduced toxicity of biogenic particles was noted, which makes them advantageous for in vivo applications, such as drug delivery, or MRI imaging of tumors. Adaptability to surface modification based on natural biochemical processes is also noted, as well as good compatibility with tumor cells and proliferation in them. Advances in the bionanotechnology field should lead to the implementation of MNPs in clinical trials.

show abstract

5-Fluorouracil-containing inorganic iron oxide/platinum nanozymes with dual drug delivery and enzyme-like activity for the treatment of breast cancer

Cited by 22 publications

References 58 publications

Magnetic iron oxide-based nanozymes: from synthesis to application

Magnetic iron oxide-based nanozymes: from synthesis to application

Smart Nanozymes for Cancer Therapy: The Next Frontier in Oncology

Biosensors and Drug Delivery in Oncotheranostics Using Inorganic Synthetic and Biogenic Magnetic Nanoparticles

Contact Info

Product

Resources

About