5-fluorouracil and curcuminoids extract from Curcuma longa L. loaded into nanohydroxyapatite as a drug delivery carrier for SKOV-3 and HepG2 cancer cells treatment

Phuong, Nguyen Thu; Wilczewski, Sławomir; Lewandowski, Jakub; Majkowska-Pilip, Agnieszka; Żelechowska-Matysiak, Kinga; Nieciecka, Dorota; Studziński, Waldemar; Olusegun, Sunday J.; Syczewski, Marcin; Giersig, Michael; Dinh, Thi Mai Thanh; Krysiński, Paweł; Osial, Magdalena

doi:10.1016/j.ceramint.2023.05.123

Cited by 6 publications

(1 citation statement)

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“…Studies have provided evidence for their efficacy in treating a spectrum of diseases, including treat neurological disorders [4], Alzheimer's disease [5], and neuropathic pain [6]. In addition, they exhibit potent anticancer [7], antidiabetic [8], antibiofilms [9], and antioxidant [10,11] properties, making them a versatile tool in the pharmacological and nutraceutical industries.…”

Section: Introductionmentioning

confidence: 99%

Application of two-level factorial design in optimization of maceration extraction of Curcuma longa curcuminoids extracts

Heryanto,

Sa’diah,

Nurcholis

2024

J App Biol Biotech

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A two-level factorial design was used to identify extraction factors that could improve Curcuma longa rhizome extraction yield (EY) and curcuminoid content (CC). These extraction factors included solid/liquid ratio (A: 0.10– 0.20 g/mL), ethanol concentration (B: 50–70%), and time maceration (C: 3–6 h). Under the prevailing circumstances, the yield of extract and CC varied from 2.86% to 20.90% and from 1.80% to 21.59%, respectively. The findings indicated that all three parameters were statistically significant (P < 0.05) in contributing to increase EY. The increase in CC was significantly influenced by ethanol concentration alone. Therefore, these findings suggest that adjusting the solid/liquid ratio, ethanol concentration, and maceration time can enhance the efficiency of curcuminoid extraction from C. longa rhizomes.

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