The synthesis of a series of isatin-N-Mannich bases derived from isatin, 5-methyl and 5-bromoisatins a s the active hydrogen component and dimethylamine, diethylamine, morpholine, piperidine, N-ethylcyclohexylamine, 3-azabicyclo[3.2.2]nonane and 3-azabicyclo[3.2. lloctane a s the secondary amine moiety is described. These compounds a r e to be screened for their pharmacological properties.