5 Chartreusin, A Glycosidic Antitumour Antibiotic from Streptomyces

Ja, Beisler

doi:10.1016/s0079-6468(08)70331-x

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Chartarin-analogs1

H Elsamicin and Other Coumarin-related Antitumor Agents1

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2015

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Cited by 12 publications

(2 citation statements)

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“…Sixteen naturally-occurring chartarin glycosides have been reported to date as bacterial metabolites (mainly from Streptomyces, Fig. 25) including the chartreusins (lambdamycins), [423][424][425][426][427][428][429][430][431][432][433] chrymutasins, [434][435][436] D329C, 437 elsamicins, [438][439][440] and hayumicins. 441 These compounds display notable antimicrobial and antitumor activities where glycosylation plays a key role in improving potency, formulation and in vivo properties wherein aminosugar-containing variants are among the most advantagous.…”

Section: Chartarin-analogsmentioning

confidence: 99%

A comprehensive review of glycosylated bacterial natural products

et al. 2015

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A systematic analysis of all naturally-occurring glycosylated bacterial secondary metabolites reported in the scientific literature up through early 2013 is presented. This comprehensive analysis of 15 940 bacterial natural products revealed 3426 glycosides containing 344 distinct appended carbohydrates and highlights a range of unique opportunities for future biosynthetic study and glycodiversification efforts.

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Section: Chartarin-analogsmentioning

confidence: 99%

A comprehensive review of glycosylated bacterial natural products

et al. 2015

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“…Elsamicin (156) is a recently discovered antitumor agent 111 that is structurally related to the anticancer compounds chartreusin (157), 112 chrysomycin V (158), and M (159), 113 gilvocarcin V (160) 114 and ravidomycin (161) (Fig. 32).…”

Section: H Elsamicin and Other Coumarin-related Antitumor Agentsmentioning

confidence: 99%