5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases

N-Arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2

“…Nucleosides 19–31 bearing the N -methyltriazole linker were prepared in a single step from 5′-azidoadenosine 39 and N -propargylsulfonamide derivatives. The latter were obtained in two steps from commercial propargylamine without a purification step ( Scheme 3 ).…”

Advancements in Antiviral Drug Development: Comprehensive Insights into Design Strategies and Mechanisms Targeting Key Viral Proteins

“…We also found that Chinese herbal monomers can be used as lead compounds to design antiviral drug candidates with better activity and lower toxicity [ 103 , 104 ]. Moreover, viral RNA cap 2'-O-methyltransferases are considered promising therapeutic targets for antiviral treatments, as they play a key role in the formation of viral RNA cap-1 structures to escape the host immune system, so inhibitors of viral RNA cap 2'-O-methyltransferases present new options [ 105 ].…”