5-Aminolevulinic Acid-mediated Photodynamic Therapy on Primary Bone Tumor and Bone Metastases Cell Lines

Sachsenmaier, Saskia Magdalen; Walter, Christian; Chen, Liang; Riester, Rosa; Wülker, Nikolaus; Danalache, Marina

doi:10.3791/63644

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2023

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“…Interestingly, 5‐ALA has been shown to induce ferroptosis in various cancer cell lines, introducing 5‐ALA as a potential local adjuvant beyond its use in FGS. An additional in vivo study explored this activity, including the description of the photodynamic therapy application of 5‐ALA that led to cell apoptosis and senescence in metastatic cancers 26 . While the results of FGS are promising and showcase safety in neurosurgical applications, future studies will need to explore the feasibility of 5‐ALA in STS patients via controlled trials.…”

Section: Emerging Technologymentioning

confidence: 99%

Emerging innovations and advancements in the treatment of extremity and truncal soft tissue sarcomas

Walker,

Simister,

Carr‐Ascher

et al. 2023

Journal of Surgical Oncology

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In this special edition update on soft tissue sarcomas (STS), we cover classifications, emerging technologies, prognostic tools, radiation schemas, and treatment disparities in extremity and truncal STS. We discuss the importance of enhancing local control and reducing complications, including the role of innovative imaging, surgical guidance, and hypofractionated radiation. We review advancements in systemic and immunotherapeutic treatments and introduce disparities seen in this vulnerable population that must be considered to improve overall patient care.

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Section: Emerging Technologymentioning

confidence: 99%