5-Aminolevulinic Acid-Hyaluronic Acid Complexes Enhance Skin Retention of 5-Aminolevulinic Acid and Therapeutic Efficacy in the Treatment of Hypertrophic Scar

Yang, Liya; Deng, Huihui; Chen, Yiman; Chen, Yuling; Guo, Ling; Feng, Ming

doi:10.1208/s12249-022-02370-1

Cited by 5 publications

(1 citation statement)

References 33 publications

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“…Severe HTS induced by facial hidradenitis suppurativa was treated with a high-concentration single dose of 5-ALA-PDT. The treatment could improve severe HTS effectively and safely, and no recurrence was observed up to 11 months of follow-up [245]. The complex of 5-ALA and HyA exhibited markedly enhanced skin retention and the increased generation and accumulation of endogenous photosensitizer (protoporphyrin IX) in vitro.…”

Section: Peripheral Vasodilator (Pentoxifylline)mentioning

confidence: 90%

Pharmacotherapy for Keloids and Hypertrophic Scars

Murakami,

Shigeki

2024

IJMS

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Keloids (KD) and hypertrophic scars (HTS), which are quite raised and pigmented and have increased vascularization and cellularity, are formed due to the impaired healing process of cutaneous injuries in some individuals having family history and genetic factors. These scars decrease the quality of life (QOL) of patients greatly, due to the pain, itching, contracture, cosmetic problems, and so on, depending on the location of the scars. Treatment/prevention that will satisfy patients’ QOL is still under development. In this article, we review pharmacotherapy for treating KD and HTS, including the prevention of postsurgical recurrence (especially KD). Pharmacotherapy involves monotherapy using a single drug and combination pharmacotherapy using multiple drugs, where drugs are administered orally, topically and/or through intralesional injection. In addition, pharmacotherapy for KD/HTS is sometimes combined with surgical excision and/or with physical therapy such as cryotherapy, laser therapy, radiotherapy including brachytherapy, and silicone gel/sheeting. The results regarding the clinical effectiveness of each mono-pharmacotherapy for KD/HTS are not always consistent but rather scattered among researchers. Multimodal combination pharmacotherapy that targets multiple sites simultaneously is more effective than mono-pharmacotherapy. The literature was searched using PubMed, Google Scholar, and Online search engines.

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Section: Peripheral Vasodilator (Pentoxifylline)mentioning

confidence: 90%