5-Alkylated thiazolidinones as follicle-stimulating hormone (FSH) receptor agonists

Wrobel, Jay; Jetter, James; Kao, Wenling; Rogers, John F.; Di, Li; Chi, Jamin; Pérez, M; Chen, Gi-Chung; Shen, Emily S.

doi:10.1016/j.bmc.2006.04.012

Cited by 53 publications

(36 citation statements)

References 13 publications

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“…4-Thiazolidinone analogues possess wide spectrum of biological activities, such as anti-inflammatory, 10 anticonvulsant, 11 antibacterial, 12,13 antifungal, 14,15 ischemic, 16 FSH receptor agonist, 17 anti-HIV 18 and anticancer 19 activities.…”

Section: 9mentioning

confidence: 99%

Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

Thomas¹,

Nanda²,

Kothapalli³

et al. 2011

Journal of the Korean Chemical Society

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ABSTRACT. A series of isonicotinyl hydrazones and their 4-thiazolidinones have been synthesized by condensation of isonicotinic acid hydrazide with various aromatic aldehydes to yield Schiff's bases, followed by the cyclocondensation of Schiff's bases with 2-mercaptoacetic acid to yield their 4-thiazolidinones. The synthesized compounds have been characterized by their elemental, analytical and spectral studies. All these compounds were evaluated for their invitro antimicrobial activity against a spectrum of non-resistant and resistant microbial organisms. These studies proved that compounds 5e,i against B. subtilis; 5e,f,h against B. anthracis; 5g,i against S. aureus showed good activity at lower concentrations. Compounds 5d-5i displayed significant activity against resistant strain of K. pneumonia with minimum inhibitory potency in the concentration range of 2-16 ug/ml.

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Section: 9mentioning

confidence: 99%

Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

Thomas¹,

Nanda²,

Kothapalli³

et al. 2011

Journal of the Korean Chemical Society

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“…Res. 5(6), 2136-2143 2137 cardiovascular [14], anti-inflammatory [15], antidiabetic [16], antihyperlipidemic [17], antimicrobial [18], antituberculosis [19], antiparasitis [20], FSH agonist [21], antiarthritic [22 ] and antidiarrhoeal [23] activity.…”

Section: Issn: 2320-5407mentioning

confidence: 99%

Synthesis and Characterization of Schiff Bases and Thiazolidinone Derivatives and Their Microbial Evaluation.

Patel¹,

Tailor²,

Patel³

et al. 2017

IJAR

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“…Обнаружено, что высокой активностью агонистов рецептора ФСГ обладают производные тиазолидин-4-она [32][33][34]. На первом этапе на основе скрининга 120 тысяч соединений были обнаружены два вещества, которые со значениями EC 50 20-50 мкМ активировали рецептор ФСГ и стимулировали АЦ (вещества 4 и 5, рис.…”

Section: рисунокunclassified

Low-molecular regulators of polypeptide hormones receptors containing LGR-repeats

Шпаков

Shpakova

2010

BIOMED KHIM

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During the last years the low-molecular non-peptidic regulators of the polypeptide hormones receptors containing LGR-repeats were identified. In the review the data on the structure and the molecular mechanisms of action of these regulators as agonists and antagonists of the luteinizing, follicle-stimulating and thyrotropin hormones are analyzed and systematized. The regulators interact with the serpentine domain of LGR-receptor and trigger the signaling cascades coupled with the receptor. Low-molecular agonists and antagonists of the LGR-receptors are considered as a new generation of the drugs that regulates the functional activity of sensitive to pituitary glycoprotein hormones signaling systems with high efficiency and selectivity. These regulators are more accessible compared to the hormones and can be use orally.

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5-Alkylated thiazolidinones as follicle-stimulating hormone (FSH) receptor agonists

Cited by 53 publications

References 13 publications

Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

Synthesis and Antimicrobial Activity of N-[2-(aryl/substituted aryl)-4-oxo-1,3-thiazolidin-3-yl]pyridine-4-carboxamide

Synthesis and Characterization of Schiff Bases and Thiazolidinone Derivatives and Their Microbial Evaluation.

Low-molecular regulators of polypeptide hormones receptors containing LGR-repeats

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