5-(6-Hydroxy-6-methyl-5-oxoheptan-2-yl)-2-methyl Phenyl Acetate

Rahayu, Maya Damayanti; Kusumaningrum, Susi; Hayun, Hayun

doi:10.3390/m1041

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“…Potassium permanganate (KMnO 4 ) is an important strong oxidizing agent which is very useful for oxidizing carbon-carbon double bonds in organic compounds [14]. We have recently reported the oxidation of 1-O-acetyl-xanthorrhizol using permanganate to obtain an α-hydroxyl ketone of the compound, but the synthesis of other derivatives and evaluation of their biological activities have not been reported [15].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Acetyl and Benzoyl Esters of Xanthorrhizol and Its Oxidation Products and Evaluation of Their Inhibitory Activity Against Nitric Oxide Production

Rahayu¹,

Kusumaningrum²,

Hayun

2020

Int J App Pharm

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Objective: Xanthorrhizol is known to have anti-inflammatory activity. However, new xanthorrhizol derivatives with improved anti-inflammatoryactivity and reduced toxicity are needed.Methods: In this study, the derivatives of xanthorrhizol were synthesized and spectroscopically characterized, and their inhibitory activities againstnitric oxide (NO) production were evaluated in RAW 264.7 macrophage cells.Results: The first stage of synthesis produced compounds 2a and 2b in 58.49% and 63.26% yields, respectively. Compounds 2a and 2b were oxidizedusing potassium permanganate, giving compounds 3a and 3b in yields of 51.92% and 43.78%, respectively. Compounds 1, 2a, 3a, and 3b alongwith diclofenac sodium (the positive control) exhibited IC50 values for NO production of 31.82, 73.85, 354.05, 97.19, and 78.43 μM, respectively. Incontrast, compound 2b did not show any inhibitory activity. Based on cytotoxicity assay, compounds 1, 2a, 2b, 3a, 3b, and diclofenac sodium had LD50values of 30.97, 65.15, 31.15, 117.86, 53.40, and 51.67 μM, respectively. The NO inhibitory activities of compounds 2a, 3a, and 3b were lower than thatof xanthorrhizol (compound 1). However, cytotoxicity tests showed that compounds 2a, 3a, and 3b had reduced toxicities compared to xanthorrhizol.Conclusion: The modification of xanthorrhizol through esterification and oxidation produced derivative compounds with weaker anti-inflammatoryactivity but reduced cytotoxicity.

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Section: Introductionmentioning

confidence: 99%