5-(3-Nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbaldehyde

Singh, Pawan; Negi, Jagmohan S.; Pant, G.; Rawat, Mahiraj Singh

doi:10.3390/m650

Cited by 3 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 1 H NMR spectra of the compounds revealed the presence of a doublet integrated for one proton at 9.72-10.32 ppm due to the NH proton of the pyrazoline ring. Treatment of 3a-d with hydrazine hydrate in formic acid aff orded the corresponding 4, 5-dihydro-1 H -pyrazole-1-carbaldehydes 5a-d [ 34 ] , while reaction of 3a-d with hydrazine hydrate in refl uxing acetic acid resulted in the formation of 4,5-dihydro-1 H -pyrazol-1-yl) ethanones 6a-d [ 35 ] . The N-formyl and acetyl groups were established using IR and 1 H NMR spectra whereas IR showed a strong absorption band at υ around 1 679-1 676 cm − 1 for the carbonyl group.…”

Section: ▼ Chemistrymentioning

confidence: 99%

Design, Synthesis and Evaluation of some Novel Pyrazoline Derivatives as Potential Anti-inflammatory and Antitumor Agents

Khalil

et al. 2013

Drug Res (Stuttg)

View full text Add to dashboard Cite

A new series of pyrazoline derivatives was designed and synthesized with the objective of developing agents with anti-inflammatory activity together with chemoprevention of hepatobiliary malignancies. The prepared compounds were evaluated for their anti-inflammatory activity using carrageenan-induced granuloma bioassay, using celecoxib as a reference drug. Ulcerogenic effect and acute toxicity profiles (ALD50) for the most active compounds were also determined. Compound 5c was proved to display anti-inflammatory activity better than celecoxib. Compounds 4b, 5d, 5c and 8 were found to be safer than indomethacin with respect to ulcerogenic effect and were well tolerated by the experimental animals with high safety margin (ALD50 >300 mg/Kg). Moreover, histopathological examination was carried out to detect the anti-inflammatory effect of the tested compounds on the livers of carrageenan-injected rats. On the other hand, compounds 4b, 4c, 4d, 5b, 5c, 5d, 6a, 6b, 6c, 6d, 8 and 9 were selected by the NCI to be evaluated for their anticancer activities but none has passed to the 5-dose assay. In addition, the ligand-receptor interactions of the most active compounds with COX-2 were investigated by performing docking studies using Molecular Operating Environment (MOE) version 2008.10.

show abstract

Section: ▼ Chemistrymentioning

confidence: 99%