5-[18F]Fluoroalkyl pyrimidine nucleosides: probes for positron emission tomography imaging of herpes simplex virus type 1 thymidine kinase gene expression

Abstract

F] 1f showed higher initial uptake (3.5-fold and 1.4-fold, respectively) in RG2TK+ tumors than control tumors, with continued washout of activity from both tumors over time. Conclusions-Biological

Biological Utility of Fluorinated Compounds: from Materials Design to Molecular Imaging, Therapeutics and Environmental Remediation

“…The most commonly used molecule for 18 F PET is 2-deoxy-2- 18 F-fluoro-β- d -glucose ( 18 F-FDG), a biologically active molecule, for early detection of tumors and assessment of response to cancer therapy by determining changes in glucose metabolism. A number of other types of 18 F-labeled compounds, including 5- 18 F-fluorouracil (5- 18 F-FU) and 18 F-thymidine analogues (e.g., 3′-deoxy-3′- 18 F-fluorothymidine ( 18 F-FLT), can be used as a marker of proliferation that is more specific to tumor tissues than 18 F-FDG). ,, 18 F-pyrimidine nucleoside analogues (e.g., 5- 18 F-fluoroalkyl-2′-deoxyuridines and 2′-fluoro-2′-deoxy-5- 18 F-fluoroalkyl-1-β- d -arabinofuranosyl uracils for imaging herpes simplex virus type-1 thymidine kinase (HSV1- tk ) gene expression), 18 F- N -methyl lansoprazole ( 18 F-NML) as tau imaging agent, 18 F- trans -5-oxocene ( 18 F-oTCO) for neurotensin receptor (NTR) imaging, 18 F- trans- cyclooctene ( 18 F-sTCO)/NT/tetrazine for targeted imaging of tumor, , aluminum 18 F-1,4,7-triazacyclononane-1,4,7-triacetic acid (NOTA)-NT as NTR targeted PET contrast agent for pancreatic ductal adenocarcinoma, 18 F-tryptophan for imaging indoleamine 2,3-dioxygenase, and 18 F-labeled aptamer have been developed for (pre)­clinical use (Table ).…”