5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Colon Cancer Risk: a Meta-analysis

Fang, Xinyu; Xu, Wangdong; Huang, Qian; Yang, Xiao‐Ke; Liu, Yanyan; Leng, Rui‐Xue; Pan, Hai‐Feng; Ye, Dong-Qing

doi:10.7314/apjcp.2014.15.19.8245

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Polymorphisms in the MTHFR gene could alter the enzyme activity and influence the capacity of the MTHFR enzyme, thereby altering the folate metabolism, and DNA synthesis and repair. Previous studies have reported an association between the polymorphisms in the MTHFR gene and increased risk of several types of cancers, such as head and neck cancer, childhood leukemia, lung cancer, colon cancer, and skin cancer (Deng et al, 2014;Fang et al, 2014;Niu et al, 2015;Pei et al, 2015;. However, the results of these studies have been inconsistent, with the differences generally being attributed to the different types of cancers, sample size, and study populations.…”

Section: Discussionmentioning

confidence: 99%

Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk

Zhang¹,

Liu²,

Li³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We performed a case-control study to investigate the association between single nucleotide polymorphisms in the MTHFR gene (677C/T and 1298A/C) and risk of breast cancer. This case-control study included 216 breast cancer cases and 216 controls. The MTHFR 677C/T and 1298A/C gene polymorphisms were assessed by polymerase chain reaction restriction fragment length polymorphism. We observed an increased likelihood of breast cancer patients having a higher age at menarche and first live birth, and a greater family history of breast cancer, especially among first-degree relatives. In addition, individuals with the TT genotype of MTHFR 677C/T were associated with increased risk of breast cancer by logistic regression analysis; the adjusted odds ratio (95%CI) was 3.05 (1.17-8.87). In conclusion, the results of our study indicated that the MTHFR C677T gene polymorphism could play a role in the development of breast cancer.

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Section: Discussionmentioning

confidence: 99%

Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk

Zhang¹,

Liu²,

Li³

et al. 2015

Genet. Mol. Res.

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“…If the heterogeneity test result returned P > 0.1, the pooled ORs were analyzed using the random-effects model ( DerSimonian and Laird, 1986 ), or else, the fixed effects model was used ( Mantel and Haenszel, 1959 ). Sensitivity analyses were also performed after sequential removal of each study ( Fang et al, 2014 ). We also tried to assess the source of heterogeneity by region, publication year, control source, and sample size ( He et al, 2014; Xue et al, 2014 ).…”

Section: Methodsmentioning

confidence: 99%

Association between glutathione S-transferase P1 Ile (105) Val gene polymorphism and chronic obstructive pulmonary disease: A meta-analysis based on seventeen case–control studies

Yang

Xiang

et al. 2015

Meta Gene

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IntroductionPrevious studies have shown that glutathione S-transferase P1 (GSTP1) was associated with chronic obstructive pulmonary disease (COPD). However, the association between GSTP1 Ile (105) Val gene polymorphism and COPD remains controversial. To drive a more precise estimation, we performed a meta-analysis based on published case–control studies.MethodsAn electronic search of PubMed, EMBASE, Cochrane library, Web of Science and China Knowledge Resource Integrated (CNKI) Database for papers on GSTP1 Ile (105) Val gene polymorphism and COPD risk was performed. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association in the homozygote model, heterozygote model, dominant model, recessive model and an additive mode. Statistical heterogeneity, test of publication bias and sensitivity analysis was performed. The software STATA (Version 13.0) was used data analysis.ResultsOverall, seventeen studies with 1892 cases and 2012 controls were included in this meta-analysis. The GSTP1 Ile (105) Val polymorphism showed pooled odds ratios for the homozygote comparison (OR = 1.501, 95%CI [0.862, 2.614]), heterozygote comparison (OR = 0.924, 95%CI [0.733, 1.165]), dominant model (OR = 1.003, 95%CI [0.756, 1.331]), recessive model (OR = 1.510, 95%CI [0.934, 2.439]), and an additive model (OR = 1.072, 95%CI [0.822, 1.398]).ConclusionsIn conclusion, the current meta-analysis, based on the most updated information, showed no significant association between GSTP1 Ile (105) Val gene polymorphism and COPD risk in any genetic models. The results of subgroup analysis also showed no significant association between GSTP1 Ile (105) Val gene polymorphism and COPD risk in Asian population and Caucasian population. Further studies involving large populations and careful control with age, sex, ethnicity, and cigarette smoking are greatly needed.

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“…Simultaneously, the 5-methyltetrahydrofolate is the main circulatory form of folate in the body and provides a methyl group to convert the amino acid homocysteine into methionine, which is the precursor of S-adenosylmethionine (SAM). SAM is the major methyl donor in the cell and takes part in DNA methylation [ 8 ]. Therefore, MTHFR not only plays a role in making proteins and other important compounds, but also is an important factor in DNA methylation, synthesis, and repair [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis

Qin

Wang

et al. 2017

Bioscience Reports

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The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer (CRC) susceptibility has been researched in numerous studies. However, the results of these studies were controversial. Therefore, the objective of this meta-analysis was to offer a more convincible conclusion about such association with more included studies. Eligible studies published till May 1, 2017 were searched from PubMed, Embase, Web of Science, and CNKI database about such association. Pooled odds ratios (ORs) together with 95% confidence intervals (CIs) were calculated to evaluate such association. And the Begg’s funnel plot and Egger’s test were applied to assess the publication bias. This meta-analysis contained 37049 cases and 52444 controls from 87 publications with 91 eligible case–control studies. Because of lack of data for a particular genotype in several studies, all the included studies were analysed barely in the dominant model. Originally, there was no association between MTHFR C677T polymorphism and CRC susceptibility (OR =0.99, 95% CI =0.94–1.05). After excluding 13 studies according to their heterogeneity and publication bias, rs1801133 polymorphism was found to reduce the risks of CRC significantly (OR =0.96, 95% CI =0.94–0.99). In the subgroup analysis of ethnicity, there was a significant association in Asians (OR =0.94, 95% CI =0.89–1.00). Furthermore, when stratified by the source of controls and genotyping methods, the positive results were observed in population-based control group (OR =0.97, 95% CI =0.93–1.00) and PCR-restriction fragment length polymorphism (PCR-RFLP) method (OR =0.95, 95% CI =0.91–0.99. The results of the meta-analysis suggested that MTHFR C677T polymorphism was associated with CRC susceptibility, especially in Asian population.

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5,10-Methylenetetrahydrofolate Reductase Polymorphisms and Colon Cancer Risk: a Meta-analysis

Cited by 6 publications

References 31 publications

Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk

Association between MTHFR 677C/T and 1298A/C gene polymorphisms and breast cancer risk

Association between glutathione S-transferase P1 Ile (105) Val gene polymorphism and chronic obstructive pulmonary disease: A meta-analysis based on seventeen case–control studies

Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis

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