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Khalbuss, Walid E.

doi:10.1186/1742-6413-2-18

Cited by 8 publications

(3 citation statements)

References 7 publications

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“…One year from diagnosis there is no evidence of recurrence disease. Other clinical trials confirmed the advantage, in terms of overall survival, of treating neuroendocrine bladder cancer with platinum-based chemotherapy [ 3 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 91%

“…SCC of the urinary bladder (SCCUB) is a rare and poorly-differentiated kind of bladder cancer, accounting for less than 1% of all primary bladder carcinomas [ 2 ], and it generally coexists with transitional cells carcinoma [ 3 ]. NET is associated with more aggressive behavior and worse prognosis compared to transitional cells carcinomas of the urinary bladder (UCUB) [ 4 ], and similarly to SCCs, usually arise in other organs.…”

Section: Introductionmentioning

confidence: 99%

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Neoadjuvant Chemotherapy in Neuroendocrine Bladder Cancer: A Case Report

et al. 2016

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Patient: Male, 71Final Diagnosis: Neuroendocrine cancer bladderSymptoms: Dysuria • haematuriaMedication: —Clinical Procedure: Transurethral resection of the bladder tumorSpecialty: OncologyObjective:Rare diseaseBackground:Small cell carcinoma of the urinary bladder is a rare and aggressive form of bladder cancer that mainly presents at an advanced stage. As a result of its rarity, it has been described in many case reports and reviews but few retrospective and prospective trials, showing there is no standard therapeutic approach. In the literature the best therapeutic strategy for limited disease is the multimodality treatment and most authors have extrapolated treatment algorithms from the therapy recommendations of small cell lung cancer.Case Report:A 71-year-old male patient was referred to our hospital with gross hematuria and dysuria. Imaging and cystoscopy revealed a vegetative lesion of the bladder wall. A transurethral resection of the bladder was performed. Pathological examination revealed a pT2 high-grade urothelial carcinoma with widespread neuroendocrine differentiation. Multimodal treatment with neoadjuvant platinum-based chemotherapy was performed. A CT scan performed after chemotherapy demonstrated a radiological complete response. The patient underwent radical cystectomy and lymphadenectomy. The histopathological finding of bladder and node specimen confirmed a pathological complete response. A post-surgery CT scan showed no evidence of local or systemic disease. Six months after surgery, the patient is still alive and disease-free.Conclusions:A standard treatment strategy of small cell cancer of the urinary bladder is not yet well established, but a multimodal treatment of this disease is the best option compared to surgical therapy alone. The authors confirm the use of neoadjuvant chemotherapy in limited disease of small cell carcinoma of the urinary bladder.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Neoadjuvant Chemotherapy in Neuroendocrine Bladder Cancer: A Case Report

et al. 2016

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“…[ 6 7 ] In addition, short chains with nuclear molding of lymphoma cells may have misleading similarities to small cell carcinoma. [ 8 ] In the urine specimen, neoplastic cells of small cell carcinoma often show loose clusters and isolated single cells with scant cytoplasm, mimicking those of lymphoma cells. [ 8 ] These are of particular concern and may have misleading similarities to epithelial neoplasms when examining lymphoma involving the urinary bladder.…”

Section: Discussionmentioning

confidence: 99%

Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report

ADACHI

Yamazaki

Liang

et al. 2015

J Cytol

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We report a rare case of a 69-year-old woman in whom diffuse large B-cell lymphoma (DLBCL) originated from the uterus and involved the urinary bladder. The cervical smears of the case mostly consisted of discohesive atypical round cells, which were highly suggestive of lymphoma; however, in voided urine smears, a majority of the cells formed large aggregates of degenerated cells, mimicking those of urothelial carcinoma (UC). The smears also represented some small loose clusters, in which tumor cells formed short chains with nuclear molding, mimicking those of small cell carcinoma. The cytodiagnosis got definitive when we identified the atypical cells that showed CD20+/CD3-/cytokeratin-/NSE- immunophenotype. These are of particular concern as they may have misleading similarities to other epithelial neoplasms when examining lymphoma involving the urinary bladder. Accordingly, this case highlights the importance of immunocytochemistry to rule out malignant lymphoma when encountering large and/or small loose clusters of atypical round cells on urinary cytology.

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Advances in Fluorescence‐BasedIn vivoFlow Cytometry for Cancer Applications

Greiner¹,

Georgakoudi²

2011

Advanced Optical Flow Cytometry

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Cited by 8 publications

References 7 publications

Neoadjuvant Chemotherapy in Neuroendocrine Bladder Cancer: A Case Report

Neoadjuvant Chemotherapy in Neuroendocrine Bladder Cancer: A Case Report

Primary uterine diffuse large B-cell lymphoma involving the urinary bladder with urinary cytology mimicking carcinomas: A case report

Advances in Fluorescence‐BasedIn vivoFlow Cytometry for Cancer Applications

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