4D in vivo dose verification for real‐time tumor tracking treatments using EPID dosimetry

Aftabi, Sajjad; Sasaki, David; VanBeek, Timothy; Pistorius, Stephen; McCurdy, Boyd

doi:10.1016/j.meddos.2020.07.003

Cited by 2 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The CCMB inhouse method was validated for in vivo dose reconstruction on 4D CT data sets using a dynamic thorax phantom and lung tumour insert [36] showing a gamma pass rate (3%, 3 mm DTA) within the PTV of >99.3%. The method was also validated for non-coplanar beam configurations such as those used in stereotactic radiosurgery (SRS) brain treatments [37], using an IMRT QA phantom with irradiations delivered via XML scripting in research mode on a TrueBeam linac (Varian Medical Systems, Palo Alto, CA), achieving gamma pass rates (2%, 2 mm DTA) >97%.…”

Section: Validation Of Algorithmsmentioning

confidence: 99%

EPID-based in vivo dosimetry – new developments and applications

McCurdy

2023

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

In vivo dosimetry has been shown to be a powerful quality assurance method in modern radiation therapy. The most common tool used for in vivo dosimetry is the electronic portal imaging device (EPID) which can quantitatively image the therapeutic beam fluence exiting the patient during treatment delivery. Since the last major literature review on this topic was published five years ago, the radiation oncology community has shown continued strong interest in this subject. Commercial options have become more widely available, with a related increase in validation efforts and sensitivity testing, while new applications continue to be explored. Work has been done to understand and increase the accuracy of the EPID for dosimetric applications, as well as continued efforts to provide practical, quantitative experiences from clinical implementation of in vivo dosimetry systems. This review examines the published literature related to in vivo EPID dosimetry from January 2017 to February 2022. The literature is classified into three main topical areas: (1) new or improved algorithmic developments including validation work, (2) applications of the in vivo EPID dosimetry method, and (3) error identification and error sensitivity analyses.

show abstract

Section: Validation Of Algorithmsmentioning

confidence: 99%

EPID-based in vivo dosimetry – new developments and applications

McCurdy

2023

J. Phys.: Conf. Ser.

View full text Add to dashboard Cite

show abstract

“…These systems make use of a flat panel detector including a scintillating layer and an array of photodiodes to determine the transmitted X-ray dose. Through forward-or back-projection methods, this information can then be used to verify the treatment delivery inside the patient in three dimensions (3D) [5,6]. However, the existing vendor-user gap, non-water equivalence of the detector, and the difficulty in defining meaningful parameters to identify when a treatment plan is compromised have slowed down clinical implementation [4,7].…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Investigation of Radiation-Sensitive Ultrasound Contrast Agents for Photon Dosimetry

Carlier,

Heymans,

Nooijens

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Radiotherapy treatment plans have become highly conformal, posing additional constraints on the accuracy of treatment delivery. Here, we explore the use of radiation-sensitive ultrasound contrast agents (superheated phase-change nanodroplets) as dosimetric radiation sensors. In a series of experiments, we irradiated perfluorobutane nanodroplets dispersed in gel phantoms at various temperatures and assessed the radiation-induced nanodroplet vaporization events using offline or online ultrasound imaging. At 25 °C and 37 °C, the nanodroplet response was only present at higher photon energies (≥10 MV) and limited to <2 vaporization events per cm2 per Gy. A strong response (~2000 vaporizations per cm2 per Gy) was observed at 65 °C, suggesting radiation-induced nucleation of the droplet core at a sufficiently high degree of superheat. These results emphasize the need for alternative nanodroplet formulations, with a more volatile perfluorocarbon core, to enable in vivo photon dosimetry. The current nanodroplet formulation carries potential as an innovative gel dosimeter if an appropriate gel matrix can be found to ensure reproducibility. Eventually, the proposed technology might unlock unprecedented temporal and spatial resolution in image-based dosimetry, thanks to the combination of high-frame-rate ultrasound imaging and the detection of individual vaporization events, thereby addressing some of the burning challenges of new radiotherapy innovations.

show abstract

4D in vivo dose verification for real‐time tumor tracking treatments using EPID dosimetry

Cited by 2 publications

References 29 publications

EPID-based in vivo dosimetry – new developments and applications

EPID-based in vivo dosimetry – new developments and applications

A Preliminary Investigation of Radiation-Sensitive Ultrasound Contrast Agents for Photon Dosimetry

Contact Info

Product

Resources

About