4D Biomaterials for Light‐Guided Angiogenesis

Farrukh, Aleeza; Paez, Julieta I.; Campo, Aránzazu del

doi:10.1002/adfm.201807734

Cited by 47 publications

(57 citation statements)

References 69 publications

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“…[ 270,272 ] The concept of photocleavable presentation of cell‐adhesive RGDS ligands has been demonstrated for in vivo vascularization and in vitro studies of light‐guided angiogenesis and cell migration. [ 270,298 ]…”

Section: Fabrication Strategies To Generate Microfluidic and Vascularmentioning

confidence: 99%

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Pradhan

Banda

Farino

et al. 2020

Adv Healthcare Materials

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The vascular system is integral for maintaining organ‐specific functions and homeostasis. Dysregulation in vascular architecture and function can lead to various chronic or acute disorders. Investigation of the role of the vascular system in health and disease has been accelerated through the development of tissue‐engineered constructs and microphysiological on‐chip platforms. These in vitro systems permit studies of biochemical regulation of vascular networks and parenchymal tissue and provide mechanistic insights into the biophysical and hemodynamic forces acting in organ‐specific niches. Detailed understanding of these forces and the mechanotransductory pathways involved is necessary to develop preventative and therapeutic strategies targeting the vascular system. This review describes vascular structure and function, the role of hemodynamic forces in maintaining vascular homeostasis, and measurement approaches for cell and tissue level mechanical properties influencing vascular phenomena. State‐of‐the‐art techniques for fabricating in vitro microvascular systems, with varying degrees of biological and engineering complexity, are summarized. Finally, the role of vascular mechanobiology in organ‐specific niches and pathophysiological states, and efforts to recapitulate these events using in vitro microphysiological systems, are explored. It is hoped that this review will help readers appreciate the important, but understudied, role of vascular‐parenchymal mechanotransduction in health and disease toward developing mechanotherapeutics for treatment strategies.

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Section: Fabrication Strategies To Generate Microfluidic and Vascularmentioning

confidence: 99%

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Pradhan

Banda

Farino

et al. 2020

Adv Healthcare Materials

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“…Hydrogels, which are responsive to external stimuli (e.g., pH, temperature, redox, light), have many applications in science and technology, ranging from regenerative medicine to soft robotics. Photoresponsive hydrogels are a kind of stimuli‐responsive hydrogels that are under intense investigation 1–6. The photoresponsiveness of gels is mainly based on photoreactions that change the crosslinking density,1,6 topology,7 and other physiochemical properties of hydrogels 8–10.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

“…Compared to other stimuli, light has high spatiotemporal resolution, enables remote control of hydrogels, and can be obtained from the sun. Therefore, light has been used to fabricate 3D extracellular matrices in hydrogels, [1,3,4] induce cargo release from hydrogels, [6,11] regulate adhesion, [12] and control the motion of actuators. [13,14] Although photoresponsive hydrogels function normally at room temperature, they lose photoresponsiveness below the freezing temperature of water because the frozen matrix hinders photoreactions and structural changes in the hydrogels.…”

mentioning

confidence: 99%

“…Photoresponsive hydrogels are a kind of stimuli-responsive hydrogels that are under intense investigation. [1][2][3][4][5][6] The photoresponsiveness of gels is mainly based on photoreactions that change the complex is replaced by another ligand upon light irradiation. [21][22][23][24][25][26][27][28] Although some Ru complexes exhibit reversible ligand photosubstitution, [21][22][23][24] their reactivity at subzero temperatures has not been explored.…”

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confidence: 99%

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Metallopolymer Organohydrogels with Photo‐Controlled Coordination Crosslinks Work Properly Below 0 °C

et al. 2020

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Controlling the structures and functions of gels is important for both fundamental research and technological applications. Introducing photoresponsive units into gels enables remote control of their properties with light. However, existing gels show photoresponsiveness only at room temperature or elevated temperatures. The development of photoresponsive gels that work below 0 °C can expand their usage in cold environments. Here, photoresponsive metallopolymer organohydrogels that function even at −20 °C are reported. The organohydrogels are prepared using photoresponsive Ru–thioether coordination bonds as reversible crosslinks to form polymer networks. A water/glycerol mixture is used as an anti‐freezing solvent. At −20 °C, the Ru–thioether coordination bonds are dissociated under light irradiation and reformed reversibly in the dark, which result in alternating crosslinking densities in the polymer networks. This process enables inducing reversible gel‐to‐sol transitions, healing damaged gels, controlling the mechanical properties and volumes of the gels, and rewriting microstructures on the gels below 0 °C.

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Tuning the Local Availability of VEGF within Glycosaminoglycan‐Based Hydrogels to Modulate Vascular Endothelial Cell Morphogenesis

Limasale

Atallah

Werner

et al. 2020

Adv Funct Materials

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Incorporation of sulfated glycosaminoglycans (GAGs) into cell-instructive polymer networks is shown to be instrumental in controlling the diffusivity and activity of growth factors. However, a subtle balance between local retention and release of the factors is needed to effectively direct cell fate decisions. To quantitatively unravel material characteristics governing these key features, the GAG content and the GAG sulfation pattern of star-shaped poly(ethylene glycol) (starPEG)-GAG hydrogels are herein tuned to control the local availability and bioactivity of GAG-affine vascular endothelial growth factor (VEGF165). Hydrogels containing varying concentrations of heparin or heparin derivatives with different sulfation pattern are prepared and thoroughly characterized for swelling, mechanical properties, and growth factor transport. Mathematical models are developed to predict the local concentration and spatial distribution of free and bound VEGF165 within the gel matrices. The results of simulation and experimental studies concordantly reveal how the GAG concentration and sulfation pattern determine the local availability of VEGF165 within the cell-instructive hydrogels and how the factor-in interplay with cell-instructive gel properties-determines the formation and spatial organization of capillary networks of embedded human vascular endothelial cells. Taken together, this study exemplifies how mathematical modeling and rational hydrogel design can be combined to pave the way for precision tissue engineering.

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4D Biomaterials for Light‐Guided Angiogenesis

Cited by 47 publications

References 69 publications

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Biofabrication Strategies and Engineered In Vitro Systems for Vascular Mechanobiology

Metallopolymer Organohydrogels with Photo‐Controlled Coordination Crosslinks Work Properly Below 0 °C

Tuning the Local Availability of VEGF within Glycosaminoglycan‐Based Hydrogels to Modulate Vascular Endothelial Cell Morphogenesis

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