4D Biofabrication: 3D Cell Patterning Using Shape‐Changing Films

Stroganov, Vladislav; Pant, Jitendra; Stoychev, Georgi; Janke, Andreas; Jehnichen, Dieter; Fery, Andreas; Handa, Hitesh; Ionov, Leonid

doi:10.1002/adfm.201706248

Cited by 57 publications

(43 citation statements)

References 39 publications

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“…Several researchers have demonstrated the versatility and adaptability of stimuli‐responsive hydrogels coupled with 4D biofabrication methods for the fabrication of vascular constructs, biomimetic tissue and in vitro cancer models . One can classify the applications of stimuli‐responsive hydrogels in tissue engineering into three main groups based on the dimensional changes of the structures: 2D, 2D‐to‐3D, and 3D …”

Section: Applicationsmentioning

confidence: 99%

Transformer Hydrogels: A Review

Erol

Pantula

Liu

et al. 2019

Adv Materials Technologies

217

201

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Hydrogels, which are hydrophilic soft porous networks, are an important class of materials of broad relevance to bioanalytical chemistry, soft‐robotics, drug delivery, and regenerative medicine. Transformer hydrogels are micro‐ and mesostructured hydrogels that display a dramatic transformation of shape, form, or dimension with associated changes in function, due to engineered local variations such as in swelling or stiffness, in response to external controls or environmental stimuli. This review describes principles that can be utilized to fabricate transformer hydrogels such as by layering, patterning, or generating anisotropy, and gradients. Transformer hydrogels are classified based on their responsivity to different stimuli such as temperature, electromagnetic fields, chemicals, and biomolecules. A survey of the current research progress suggests applications of transformer hydrogels in biomimetics, soft robotics, microfluidics, tissue engineering, drug delivery, surgery, and biomedical engineering.

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Section: Applicationsmentioning

confidence: 99%

Transformer Hydrogels: A Review

Erol

Pantula

Liu

et al. 2019

Adv Materials Technologies

217

201

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“…Multiple morphing configurations are formed in one patternedh ydrogel using hole-containing mask to direct the buckling of each unit. The photolithographic strategya nd deformation principles should be applicable to other soft materialsf or programmable deformationsa nd promisinga pplicationsi nb iomedicine, [84][85][86] flexible electronics, [87,88] soft robotics, [89][90][91] etc.…”

Section: Discussionmentioning

confidence: 99%

Photolithographically Patterned Hydrogels with Programmed Deformations

Hao

et al. 2018

Chemistry An Asian Journal

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Programmed deformations are widespread in nature, providinge legantp aradigms to design self-morphing materials with promising applications in biomedical devices, flexible electronics, soft robotics, etc. In this emerging field, hydrogels are an ideal materialt oi nvestigate the deformation principle and the structure-deformation relationship. One crucial step is to construct heterogeneouss tructures in af acile yet effective way.H erein, we provide af ocus review on different deformation modes and corresponding structural features of hydrogels. Photolithography is av ersatile approach to control the outer shape of the hydrogel and spatiald istribution of the component in the hydrogel, endowing the patterned hydrogels with programmed internal stress and thus controllable deformations. Specifically, cooperative deformations take place in periodically patterned hydrogelsw ith in-plane gradients, and multiple morphing structures are formed in one patternedh ydrogel using selective preswelling to directt he buckling of each unit. The structuralc ontrol strategy and deformation principles should be applicable to other materials with broad applications in diverseareas.

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“…Hence, as actuators, they can be designed to be triggered independently from cell activity in biological tissues. For example, Teshima et al and Stroganov et al recently developed composite polymers that can roll onto themselves and can either encapsulate suspended cells in 3D or convert a planar cell culture into a 3D cylindrical culture configuration. To date, these innovative strategies require specialized biomaterials, extensive fabrication steps, and are limited to one folding mechanism.…”

Section: Introductionmentioning

confidence: 99%

Morphodynamic Tissues via Integrated Programmable Shape Memory Actuators

Kalashnikov

Moraes

2019

Adv Funct Materials

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Manipulating the shape of preformed living tissues can present a novel fabrication route toward complex biological architectures. However, external manipulation of tissues can be challenging to implement robustly at multiple length scales and with high degrees of freedom, particularly in soft fibrous tissue constructs. Here, a versatile platform is developed to drive soft tissue morphodynamics using embeddable shape memory actuators that generate multiscale, repetitive, and highly customized tissue deformation on demand. To achieve this, a thermally isolating coating technique is designed and developed for programmable shape memory wires, which protects surrounding biological materials from cytotoxic heating effects during wire actuation. The coated tissue actuators (CTAs) can then be embedded in engineered tissues and activated to produce both large-and small-scale tissue deformations in a highly customized and reproducible manner. Using this strategy, tissues can be forced to adopt specified shapes, with precise control over cell elongation and orientation within an encapsulating matrix. Furthermore, the system can produce predictable, highly localized, and customizable strains within fibrous matrices, capable of elongating cells and biasing their orientation within degrees of a desired direction. This strategy may hence have broad applicability in both applied tissue biofabrication and for fundamental studies of cell-matrix interactions.

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4D Biofabrication: 3D Cell Patterning Using Shape‐Changing Films

Cited by 57 publications

References 39 publications

Transformer Hydrogels: A Review

Transformer Hydrogels: A Review

Photolithographically Patterned Hydrogels with Programmed Deformations

Morphodynamic Tissues via Integrated Programmable Shape Memory Actuators

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