4CPS-044 Impact of clinical pharmacist-vancomycin monitoring on patient safety outcome

Abstract

days prior to hospitalisation. Crude in-hospital mortality and composite cure rate (significant resolution or complete resolution of all signs and symptoms of the infection), defined as both clinical cure and microbiological eradication were evaluated. Statistical analysis was performed using SPSS statistics v24.0. Results A total of 155 infections in 87 patients were included. Mean age was 67 (IQR 50-75) years. Median CCI was 3 (IQR 1-5). 43.9% of patients had previous hospitalisation and in 42.4% of patients antibiotics were administered previously. Thirty-three per cent of patients were transferred from another hospital or a social-sanitary centre. Death occurred in 19.4% of infections. The main infections were urologic (42.6%). 5.8% were PDR strains, 17.4% were colistin-resistant and 40.0% meropenem-resistant strains. The main systemic antibiotics used were: colistin 22.7% and meropenem 20.7%. Intratracheal and inhaled antibiotics were used in 4.0% and 1.0% of episodes respectively: 27.1% were combined treatments. Microbiological resolution was achieved in 54.2% of infections, while clinical resolution was observed in 75.5%. Non-statistically significant results were obtained when comparing the effectiveness of combination therapy versus monotherapy in achieving clinical resolution (OR:0.539; 95% CI: 0.246 to 1.181). Conclusion In our hospital these kinds of infections were produced in the older population with a moderate CCI and previous exposure to antibiotics. A high percentage of meropenem-resistant strains were found. Combination therapy was not more effective than monotherapy in achieving clinical resolution.