483 Regional Review of Paediatric Radioallergosorbent Tests(R) (Rast) over 5 Years in Ireland: an Epidemiological Study in a Defined Birth Cohort

Abstract

AbstractsResults OFC was performed in 52 neonates and positive inductions of symptoms were seen in 23 (44%) of the challenged neonates. The majority had mild digestive symptoms which disappeared immediately after elimination of the causal milk. According to the results of OFC, the sensitivity, specificity, and positive predictive value of milk-specific IgE were 0%, 93%, and 0%, and those of the allergen-specific lymphocyte stimulation test were 61%, 76%, and 67%, respectively. Conclusions Diagnostic OFCs for CMA were safely carried out in neonates. The discontinuation of certain foods as part of an elimination diet can lead to appropriate nutrition management. In NICUs, OFC should be carried out more aggressively with careful observation. REGIONAL REVIEW OF PAEDIATRIC RADIOALLERGOSORBENT TESTS® (RAST) OVER 5 YEARS IN IRELAND: AN EPIDEMIOLOGICAL STUDY IN A DEFINED BIRTH COHORT

Application of photonic crystal enhanced fluorescence to detection of low serum concentrations of human IgE antibodies specific for a purified cat allergen (Fel D1)

“…(Burks et al 2011). Sensitization can be measured by skin testing with allergen extracts (Gergen et al 1987; Hagy and Settipane 1971; Lieberman and Sicherer 2011) or blood tests (Feeney et al 2012; Rudenko et al 2013; Schellenberg and Adkinson 1975; Sicherer et al 2012; Wahyuni et al 2003). A skin test is done by monitoring a patient’s reactions after a small amount of a suspected allergen is placed on or below the skin, while a blood test is an immunoassay that measures the concentration of Immunoglobulin E (IgE) against specific allergens in the patient’s blood.…”