483 Prognostic interest to discriminate muscularis mucosae invasion (T1a vs. T1b) in non-muscle-invasive bladder carcinomas: Results from a national multicentre study with a central pathology review

Rouprêt, Morgan; Seisen, Thomas; Larré, S.; Comperat, E.; Mazerolles, C.; Fromont, Gaëlle; Celhay, O.; Faivre, D'Arcier B.; Rozet, F.; Irani, J.; Soulié, M.; Pfister, C.

doi:10.1016/s1569-9056(13)60966-5

Cited by 2 publications

(3 citation statements)

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“…For each study, the data were extracted (S2 Table). Five studies were performed in Asia (10)(11)(12)(13)(14), 20 were performed in Europe (2,7,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32), and 10 were performed in North America (33)(34)(35)(36)(37)(38)(39)(40)(41)(42). RFS was evaluated in 20 studies, PFS was evaluated in 31 studies and CSS was evaluated in 12 studies.…”

Section: Resultsmentioning

confidence: 99%

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Sub-staging specific differences in recurrence-free, progression-free and cancer-specific survival for patients with T1 bladder cancer: a systematic review and meta-analysis

Chen

Yang

Zhang

et al. 2020

Preprint

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Background: The efficiency of the T1 sub-staging system on categorizing bladder cancer (BC) patients into subgroups with different clinical outcomes was unclear. We summarized relevant evidences, including recurrence-free survival (RFS), progression-free survival (PFS) and cancer-specific survival (CSS), to analyze the prognostic significance of T1 sub-stage.Methods: Systematic literature searches of MEDLINE, EMBASE and the Cochrane Library were performed. We pooled data on recurrence, progression, and CSS from 35 studies.Results: The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) indicated the difference in RFS between T1a sub-stage and T1b sub-stage (HR1.28, 95%CI 1.14-1.43). The significant difference was observed in PFS between the two arms (HR 2.18, 95%CI 1.95-2.44). Worse CSS was found in T1b patients than T1a patients (HR 1.45, 95%CI 1.28-1.64).Conclusions: T1 sub-staging system based on the invasion depth into muscularis mucosae (MM) can be a significant prognostic factor for RFS, PFS, and CSS of patients with T1-BC. Urologists and pathologists are encouraged to work together to give a precise sub-stage classification of T1-BC, and T1 sub-staging system should be a routine part of any histopathological report when possible.Different treatment strategies need to be developed for both T1a-BC and T1b-BC.

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Section: Resultsmentioning

confidence: 99%

“…The T1 sub-stage may help categorize patients into different subgroups with different clinical outcomes. And T1 sub-stage has been identi ed as an important prognostic factor (7). The most widely studied sub-staging system for T1-BC is based on muscularis mucosae (MM) invasion.…”

Section: Introductionmentioning

confidence: 99%

Sub-staging specific differences in recurrence-free, progression-free and cancer-specific survival for patients with T1 bladder cancer: a systematic review and meta-analysis

Chen

Yang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Table 2). Five studies were performed in Asia [7][8][9][10][11], 20 were performed in Europe [1,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], and 10 were performed in North America [31][32][33][34][35][36][37][38][39][40]. RFS was evaluated in 20 studies, PFS was evaluated in 31 studies, and CSS was evaluated in 12 studies.…”

Section: Heterogeneity and Publication Biasmentioning

confidence: 99%

Sub-Staging-Specific Differences in Recurrence-Free, Progression-Free, and Cancer-Specific Survival for Patients with T1 Bladder Cancer: A Systematic Review and Meta-Analysis

et al. 2020

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Introduction: The efficiency of the T1 sub-staging system on categorizing bladder cancer (BC) patients into subgroups with different clinical outcomes was unclear. We summarized relevant evidences, including recurrence-free survival (RFS), progression-free survival (PFS), and cancer-specific survival (CSS), to analyze the prognostic significance of T1 sub-stage. Methods: Systematic literature searches of MED-LINE, EMBASE, and the Cochrane Library were performed. We pooled data on recurrence, progression, and CSS from 35 studies. Results: The pooled hazard ratios (HRs) and 95% confidence intervals (CIs) indicated the difference in RFS between T1a sub-stage and T1b sub-stage (HR 1.28, 95% CI 1.14-1.43, p < 0.001). The significant difference was observed in PFS between the 2 arms (HR 2.18, 95% CI 1.95-2.44, p < 0.001). Worse CSS was found in T1b patients than in T1a patients (HR 1.36, 95% CI 1.21-1.54, p < 0.001). Conclusions: T1 sub-staging system based on the invasion depth into muscularis mucosae can be a significant prognostic factor for RFS, PFS, and CSS of patients with T1 BC. Urologists and pathologists are encouraged to work together to give a precise sub-stage classification of T1 BC, and T1 sub-staging system should be a routine part of any histopathological report when possible. Different treatment strategies need to be developed for both T1a BC and T1b BC.

show abstract

483 Prognostic interest to discriminate muscularis mucosae invasion (T1a vs. T1b) in non-muscle-invasive bladder carcinomas: Results from a national multicentre study with a central pathology review

Cited by 2 publications

References 0 publications

Sub-staging specific differences in recurrence-free, progression-free and cancer-specific survival for patients with T1 bladder cancer: a systematic review and meta-analysis

Sub-staging specific differences in recurrence-free, progression-free and cancer-specific survival for patients with T1 bladder cancer: a systematic review and meta-analysis

Sub-Staging-Specific Differences in Recurrence-Free, Progression-Free, and Cancer-Specific Survival for Patients with T1 Bladder Cancer: A Systematic Review and Meta-Analysis

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