47Calcium absorption in parenchymatous and biliary liver disease

Whelton, M. J.; Kehayoglou, A. K.; Agnew, J. E.; Turnberg, L A; Sherlock, Sheila

doi:10.1136/gut.12.12.978

Cited by 45 publications

(14 citation statements)

References 18 publications

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“…In the study of intestinal calcium absorption alternative radioisotope techniques are available such as whole-body radioactivity counting methods (Whelton, Kehayoglou, Agnew, Turnberg & Sherlock, 1971), or techniques involving the simultaneous oral and intravenous administration of different isotopes of calcium, with subsequent deconvolution analysis of the plasma levels of these isotopes (Hart & Spencer, 1967). Such methods have been used to validate the methods based on the use of single isotopes.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Radioisotope Methods for the Measurement of Phosphate Absorption in Normal Subjects and in Patients with Chronic Renal Failure

et al. 1981

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1. Intestinal phosphate absorption was measured in normal subjects, in patients with chronic renal failure, and in post-transplant patients, by a double isotope technique involving oral administration of 32P and simultaneous intravenous injection of 33P with subsequent deconvolution analysis. 2. By this technique intestinal phosphate absorption has been shown to have two components: an initial rapid phase, which is completed by 3 h, and a slower more prolonged phase, which continues beyond 7 1/2 h. 3. Phosphate malabsorption has been demonstrated in chronic renal failure and transplant patients, which is accounted for by impairment of the initial rapid phase of absorption. 4. Results obtained by deconvolution analysis have been compared with other estimates of phosphate absorption obtained from analysis of 32P radioactivity curves alone. 5. The fractional hourly rate of absorption and the plasma 32P radioactivity at 60 min corrected for extracellular fluid volume provided the best approximations to the result obtained by deconvolution analysis, with respect to both the maximal rate of phosphate absorption and cumulative percentage phosphate absorption.

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Section: Introductionmentioning

confidence: 99%

Comparison of Radioisotope Methods for the Measurement of Phosphate Absorption in Normal Subjects and in Patients with Chronic Renal Failure

et al. 1981

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“…Osteoporosis appears to be the most common form of bone pathology (3)(4)(5); osteomalacia also occurs in some patients (6-8). Vitamin D deficiency is well documented in many patients with primary biliary cirrhosis (5,6,(8)(9)(10)(11) …”

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Intestinal Calcium Absorption and Vitamin D Status in Chronic Cholestatic Liver Disease

et al. 1984

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Metabolic bone disease is common in patients with cholestatic liver disease. The importance of vitamin D status and calcium malabsorption in the pathogenesis of bone disease in these patients remains undefined. We have measured intestinal calcium absorption in relation to vitamin D status in 14 patients with chronic cholestatic liver disease including 11 with primary biliary cirrhosis. Fractional calcium absorption was determined from radioactive counts in the right forearm after separate oral and intravenous doses of 47CaCl2 in the fasting state. Eight of 14 patients (57%) had a decreased calcium absorption compared to controls. A significant correlation was observed between serum 25-hydroxyvitamin D levels and fractional calcium absorption (r = 0.623, p less than 0.02). Treatment with oral 25-hydroxyvitamin D3 in three patients with low serum 25-hydroxyvitamin D levels resulted in correction of serum 25-hydroxyvitamin D levels and improvement in fractional calcium absorption. No correlation was found between serum 1,25-dihydroxyvitamin D levels and fractional calcium absorption (r = 0.221). Calcium malabsorption was common in this series of patients, and serum 25-hydroxyvitamin D levels were useful in predicting fractional calcium absorption. Treatment with oral 25-hydroxyvitamin D3 was accompanied by improved calcium absorption.

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“…Osteoporosis has been reported both in hepatocellular and cholestatic liver disease (Atkinson et al, 1956;Wagonfeld et al, 1976;. Malabsorption of dietary calcium occurs in cholestatic disease and to a lesser extent in chronic parenchymal liver disease, and this has been attributed to vitamin D deficiency (Kehayoglou et al, 1968;Whelton et al, 1971). 25-hydroxycholecalciferol (25(OH)D) which is formed in the liver is the precursor of the hormonally active renal metabolite 1,25-dihydroxycholecalciferol (1,25(OH)2D3) (Fraser and Kodicek, 1970).…”

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Intestinal absorption of cholecalciferol in alcoholic liver disease and primary biliary cirrhosis.

Barragry¹,

Long²,

France³

et al. 1979

Gut

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SUMMARY The intestinal absorption of (3H)cholecalciferol was studied in five patients with alcoholic liver disease, six patients with primary biliary cirrhosis, and 15 healthy subjects. The rate of appearance in plasma of (3H)cholecalciferol after oral ingestion and the subsequent appearance of (3H) polar metabolites in the alcoholic subjects were similar to those in the healthy subjects. In subjects with primary biliary cirrhosis the rate of appearance in plasma of (3H)cholecalciferol was significantly reduced. The rate of appearance of labelled polar metabolites-of cholecalciferol was also lower in this group, suggesting that increased removal of labelled vitamin by conversion into more polar metabolites could not account for the reduced plasma (3H)cholecalciferol response.

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47Calcium absorption in parenchymatous and biliary liver disease

Cited by 45 publications

References 18 publications

Comparison of Radioisotope Methods for the Measurement of Phosphate Absorption in Normal Subjects and in Patients with Chronic Renal Failure

Comparison of Radioisotope Methods for the Measurement of Phosphate Absorption in Normal Subjects and in Patients with Chronic Renal Failure

Intestinal Calcium Absorption and Vitamin D Status in Chronic Cholestatic Liver Disease

Intestinal absorption of cholecalciferol in alcoholic liver disease and primary biliary cirrhosis.

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