“…EUS can accurately delineate the depth of penetration, thus allowing for the safe en− doscopic removal of the lesion [20 ± 24]. Whether submucosal tumors can be distinguished as benign or malignant by EUS is still controversial [14,25]; however, certain tumor features ob− servable by EUS may be more suggestive of malignancy. These include size greater than 3±4 cm, poorly defined or irregular margins, presence of internal echogenic foci or cystic spaces, ad− jacent lymphadenopathy, and rapid growth rate as determined by follow−up EUS [26,27].…”