47: Like mother like daughter- low birthweight and preeclampsia tend to re-ocurre at the next generation

Sherf, Yehonatan; Vardi, Ilana Shoham; Bilenko, Natalya

doi:10.1016/j.ajog.2014.10.093

Cited by 1 publication

(5 citation statements)

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“…An opposing theory says that is not the compromised fetal environment, but rather shared genetic or environmental factors that predispose both the mother and her child to the same pregnancy complications and the same morbidities later in life 11 . This theory is strengthened by evidence that mothers and their children suffer from similar pregnancy complications 6 . According to this theory, a given genetic make up or a given environmental exposure may predispose both generations to both pre‐eclampsia and respiratory morbidity later in life.…”

Section: Discussionmentioning

confidence: 99%

“…11 This theory is strengthened by evidence that mothers and their children suffer from similar pregnancy complications. 6 According to this theory, a given genetic make up or a given environmental exposure may predispose both generations to both pre-eclampsia and respiratory morbidity later in life.…”

Section: Shaheen Et Almentioning

confidence: 99%

“…In the United States, the increasing incidence of pre‐eclampsia, which is at least partially attributed to the increase in the incidence of maternal obesity, 2,3 emphasizes the need to understand further the long‐term effects of pre‐eclampsia on the fetus. While it is already well established that pre‐eclampsia may lead to substantial morbidity and mortality of both the mother and the fetus in the short term (4‐6), the study of long‐term effects of pre‐eclampsia needs to be investigated 4–6 …”

Section: Introductionmentioning

confidence: 99%

“…1 In the United States, the increasing incidence of pre-eclampsia, which is at least partially attributed to the increase in the incidence of maternal obesity, 2,3 emphasizes the need to understand further the long-term effects of pre-eclampsia on the fetus. While it is already well established that pre-eclampsia may lead to substantial morbidity and mortality of both the mother and the fetus in the short term (4)(5)(6), the study of long-term effects of pre-eclampsia needs to be investigated. [4][5][6] The current literature focuses on the adverse outcomes occurring during the pregnancy and shortly after, such as the increased risk of fetal growth restriction, 7,8 perinatal death, 9 and severe neonatal morbidity.…”

mentioning

confidence: 99%

“…While it is already well established that pre-eclampsia may lead to substantial morbidity and mortality of both the mother and the fetus in the short term (4)(5)(6), the study of long-term effects of pre-eclampsia needs to be investigated. [4][5][6] The current literature focuses on the adverse outcomes occurring during the pregnancy and shortly after, such as the increased risk of fetal growth restriction, 7,8 perinatal death, 9 and severe neonatal morbidity. 10,11 While recent studies have reported a correlation between pre-eclampsia and long-term cardiovascular 3,12-15 and neurological 16,17 effects on the offspring, less is known about the effect on the respiratory health of the offspring.…”

mentioning

confidence: 99%

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In utero exposure to pre‐eclampsia as an independent risk factor for long‐term respiratory disease

Sacks

Friger

Shoham‐Vardi

et al. 2020

Pediatric Pulmonology

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Introduction Pre‐eclampsia has a considerable effect on the intrauterine environment, yet not much is understood about how this impacts the respiratory health of the offspring. The aim of the present study is to determine if pre‐eclampsia correlates with a higher incidence of respiratory disease in the offspring. Methods This cohort study assessed the differences in respiratory disease patterns between singletons born to mothers with and without pre‐eclampsia. The study was conducted between 1991 and 2014 in a regional tertiary medical center. A generalized estimating equation (GEE) model was used to control for confounders and maternal clusters. Results 253 808 deliveries were included in the study. Of these, 3.0% were to mothers diagnosed with pre‐eclampsia (n = 7660), 0.9% with severe pre‐eclampsia (n = 2366), and 0.03% with eclampsia (n = 81). A significant linear association was noted between the severity of the pre‐eclampsia (no pre‐eclampsia, mild, severe pre‐eclampsia, and eclampsia) and respiratory disease of the offspring (5.7%, vs 6.0% vs 7.3% vs 9.9%, respectively; P = .003). The offspring of mothers who developed pre‐eclampsia had significantly higher rates of asthma (1.1%, vs 1.3% vs 1.4% vs 1.2% correspondingly; P = .018). In the GEE model, controlling for gestational diabetes, maternal age, gestational age, and length of follow up, pre‐eclampsia was found to be an independent risk factor for respiratory morbidity in the offspring (adjusted odds ratio = 1.32; 95% confidence interval, 1.21‐1.45). Conclusion Exposure to maternal pre‐eclampsia is an independent risk factor for long‐term respiratory morbidity in the offspring. Specifically, the prenatal exposure to pre‐eclampsia was significantly associated with asthma of the offspring.

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Section: Discussionmentioning

confidence: 99%

Section: Shaheen Et Almentioning

confidence: 99%