2013
DOI: 10.1016/s0924-9338(13)75789-4
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462 – Quetiapine monotherapy in acute phase for major depressive disorder: a metaanalysis of randomized, placebo-controlled trials

Abstract: Background: Schizophrenia and bipolar depression trials suggest that quetiapine may have an antidepressant effect.Objectives: This meta-analysis aimed to determine the efficacy, acceptability and tolerability of quetiapine treatment for major depressive disorder (MDD). Only the randomized controlled trials (RCTs) comparison between quetiapine and placebo were included. The authors searched such clinical trials carried out between 1991 and February 2012.

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Cited by 5 publications
(2 citation statements)
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“…SSRIs and SNRIs in patients with anxiety and related disorders, including panic disorder, GAD, OCD, or PTSD, with comorbid MDD have been shown to be effective in improving both disorders [224,723,1359,1395]. Among the atypical antipsychotics, quetiapine has been found to have efficacy as monotherapy in both MDD [1396] and GAD [1397], as well as MDD with anxiety [1398], while case series suggest that aripiprazole augmentation of antidepressants [496], and risperidone monotherapy [267] may also reduce comorbid depressive and anxiety symptoms.…”
Section: Overviewmentioning
confidence: 99%
“…SSRIs and SNRIs in patients with anxiety and related disorders, including panic disorder, GAD, OCD, or PTSD, with comorbid MDD have been shown to be effective in improving both disorders [224,723,1359,1395]. Among the atypical antipsychotics, quetiapine has been found to have efficacy as monotherapy in both MDD [1396] and GAD [1397], as well as MDD with anxiety [1398], while case series suggest that aripiprazole augmentation of antidepressants [496], and risperidone monotherapy [267] may also reduce comorbid depressive and anxiety symptoms.…”
Section: Overviewmentioning
confidence: 99%
“…As pesquisas vêm mostrando que a quetiapina, um antipsicótico de segunda geração, além da eficácia clínica nos tratamentos da esquizofrenia e transtorno do humor bipolar, possui efeitos positivos no TDM (BAUNE, 2008;IGNÁCIO et al, 2018). Entre outros antipsicóticos de segunda geração, a quetiapina vem sendo investigada como terapia adjuvante ou como monoterapia para pacientes que não apresentam respostas terapêuticas aos antidepressivos disponíveis (MANEETON et al, 2012).…”
Section: Introductionunclassified